| چکیده انگلیسی مقاله |
Background and Aim: Polycystic Ovary Syndrome (PCOS) is the most common endocrine disorder among women and is associated with a wide range of metabolic and reproductive complications. Weight reduction and phytoestrogens have been shown to play a significant role in symptom management. This systematic review aims to critically evaluate clinical trials investigating the effects of phytoestrogens on metabolic parameters and overall health outcomes in women diagnosed with PCOS.
Methods: This systematic review analyzed clinical trials that examined the effect of phytoestrogens on metabolic and health-related indices in women with PCOS, including hormonal profiles, inflammatory markers, oxidative stress, fertility parameters, lipid profiles, gut microbiota composition, metabolic syndrome, and insulin resistance. A comprehensive literature search was performed across scientific databases, including PubMed/Medline, Scopus, ScienceDirect, Google Scholar, Cochrane Library, ISI Web of Knowledge, Embase, and SID, covering publications from October 1990 to October 2024.
Results: A total of 18 eligible clinical trials were included in the final analysis. The findings demonstrated that phytoestrogen intake could lead to a reduction in serum testosterone and luteinizing hormone (LH) levels, thereby enhancing ovulatory function. Furthermore, phytoestrogens significantly decreased pro-inflammatory markers such as IL-6, TNF-α, and CRP, indicating a potential anti-inflammatory effect. These compounds were also associated with weight loss and a reduced risk of metabolic syndrome. Additionally, phytoestrogens contributed to oxidative stress reduction, evidenced by increased glutathione levels and decreased malondialdehyde, and improved insulin resistance and gut microbiota balance. However, their effects on lipid profile components (HDL, LDL, VLDL), endometrial thickness, and reproductive outcomes showed inconsistent results across studies.
Conclusion: The results of this systematic review show the relative effectiveness of phytoestrogens in improving certain metabolic and health indicators in women with PCOS. However, further studies with more rigorous designs are necessary to evaluate the effects of these compounds, particularly in relation to lipid profiles and fertility. |
| نویسندگان مقاله |
مینو اکبرزاده مرشدی | Minoo Akbarzadeh Morshedi
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی کاشان، کاشان، ایران
محمد محمدی | Mohammad Mohammadi
Student Research Committee, Kashan University of Medical Sciences, Kashan, Iran
کمیته تحقیقات دانشجویی، دانشگاه علوم پزشکی کاشان، کاشان، ایران
آزاده امینیان فر | Azadeh Aminianfar
Research Center for Biochemistry and Nutrition in Metabolic Diseases, Kashan University of Medical Sciences, Kashan, Iran
مرکز تحقیقات بیوشیمی و تغذیه در بیماری های متابولیک، دانشگاه علوم پزشکی کاشان، کاشان، ایران
|