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Iranian Journal of Public Health، جلد ۴۶، شماره ۲، صفحات ۲۳۵-۲۴۱
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عنوان انگلیسی Caspofungin-Non-Susceptible Candida orthopsilosis Isolated from Onychomycosis in Iran
چکیده انگلیسی مقاله Background: Although Candida albicans remains the most common fungal isolate from clinical specimens, many studies have detected a shift towards non-albicans Candida species. Despite worrying clinical pictures associated with latter species , there is little information regarding its susceptibility patterns against currently available antifungal agents, with only a small number of strains having been studied. Methods: We evaluated the in vitro antifungal susceptibilities of clinical isolates of C. orthopsilosis already identified by two-steps PCR-RFLP and reconfirmed by sequence analysis of entire ITS rDNA region, to six antifungal drugs. Results: The resulting MIC 50 and MIC 90 for all strains (n=18) were in increasing order, as follows: posaconazole (0.016 & 0.063 μg/ml); itraconazole (0.031 & 0.125 μg/ml); amphotericin B (0.5 & 1 μg/ml); fluconazole (0.25 & 0.5 μg/ml) and caspofungin (4 & 8 μg/ml). A uniform pattern of the MIC ranges was seen for amphotericin B, fluconazole, itraconazole, and posaconazole, while a widest range and the highest MICs were observed for caspofungin. Conclusion: Although we emphasis on the careful species designation of the clinical isolates of Candida , the antifungal susceptibility patterns of these clinically important organisms may have an application in clinical and epidemiological setting and deserve the implementation of local surveillance programs to monitor.
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نویسندگان مقاله رسول محمدی | rasoul mohammadi


حسین میرهندی | hossein mirhendi


محمد تقی هدایتی | mohammad taghi hedayati


حمید بدلی | hamid badali


نشانی اینترنتی http://ijph.tums.ac.ir/index.php/ijph/article/view/9054
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/86/article-86-350071.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article(s)
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