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Medical Laboratory Journal، جلد ۱۸، شماره ۶، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
The effect of running and starvation intervention on the regulation of apoptotic pathway activity (xbp1) caused by endoplasmic reticulum stress in the liver of non-alcoholic fatty liver rats |
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| چکیده انگلیسی مقاله |
Background and objectives: The purpose of this research is to investigate continuous exercise and starvation in regulating the activity of the apoptotic pathway caused by endoplasmic reticulum stress in the liver of male Wistar non-alcoholic fatty model rats.
Methods :30 Wistar male obese rats, 18-20 weeks old, with an average body weight of 348 ± 25.53, , were selected as research samples. After one week familiarization with the laboratory environment, the fatty model animals were randomly divided into 6 groups of 5 Rat. The entire training course includes two familiarization stages (one week of adaptation to the research environment and treadmill) and the main training (for 4 weeks, 3 and 5 days a week for 45-60 minutes) on a treadmill with zero grade. The statistical test of one-way analysis of variance was used at a significance level of less than 0.05 and the LSD post hoc test was used among the research groups.
Results: According to the statistical results of the one-way analysis of variance, it showed a significant decrease in the ratio of lipoproteins (VLDL/HDL, LDL/HDL) in all experimental groups compared to the control group, and also a significant decrease in XBP1 and CHOP gene expression in the 5-day training groups. He showed 3-5 days of training with hunger.
Conclusion: Therefore, regular exercise along with starvation can prevent the progression of NAFLD by suppressing the excessive stress activity of the endoplasmic reticulum. |
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| کلیدواژه‌های انگلیسی مقاله |
Starvation, Exercise, Endoplasmic Reticulum, Xbp1, CHOP |
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| نویسندگان مقاله |
| mahshad Paziraee
Department of Physical Education & sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran
| habib asgharpour
Department of Physical Education & sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran
| asra askari
Department of Physical Education & sports sciences, Gorgan Branch, Islamic Azad University, Gorgan, Iran
| Reza Rezaei Shirazi
Department of Physical Education & sports sciences, Aliabad katoul Branch, Islamic Azad University, Aliabad katoul, Iran
| Neda Aghaei Bahman Beglo
Islamic Azad University
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| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-702-3&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
فیزیولوژی ورزشی |
| نوع مقاله منتشر شده |
Research Article |
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