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Iranian Journal of Public Health، جلد ۵۴، شماره ۴، صفحات ۸۱۰-۸۱۹
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عنوان انگلیسی Association of Adiponectin and Resistin Gene Polymorphisms with Undernutrition Risk among Type 2 Diabetes Patients in Bosnia and Herzegovina
چکیده انگلیسی مقاله Background: Undernutrition disorder is a prevalent comorbidity (up to 25%) in type 2 diabetes (T2D) patients which significantly compromises their health. We aimed to assess the association between single nucleotide polymorphysms (SNPs) adiponectin (ADIPOQ) +276 (G/T) and resistin (RETN) -420 (C/G) with the risk of developing T2D and undernutrition in patients with T2D. Methods: The research was conducted as prospective case-control study among 106 patients with T2D and 106 healthy control individuals in the territory of the Bosnia and Herzegovina from Sep 1st 2022 to May 1st 2023. For assessing the nutritional status, the mini nutritional assessment (MNA) was used. DNA analysis was carried out by restriction fragment length polymorphism-polymerase chain reaction (RFLP-PCR) method. The data were analyzed using chi-square test, t-test for independent samples and binary multivariate logistic regression. Results: The research included 212 subjects of which 124 (58.5%) were male. The mean age of the subjects was 68.48±4,67 yr. Almost 20% of subjects were undernourished, significantly more T2D patients when compared to controls (33% vs. 6.6%; P<0.001). ADIPOQ +276 GT genotype was identified as significant predictor of T2D (OR: 3.454; 95% CI: 1.400-8.521; P=0.007) and undernutrition disorder (OR: 3.453; 95% CI: 1.331-8.961; P=0.011) in T2D population, while the presence of RETN -420 CG genotype had protective effect against occurrence of T2D (OR: 0.353; 95% CI: 0.144-0.867; P=0.023). However, RETN genotypes were not associated with undernutrition disorder. Conclusion: ADIPOQ +276 gene polymorphism represent a significant predictor for development of T2D and undernutrition disorder in T2D population, while RETN -420 gene polymorphism was identified as a significant factor associated with a reduced risk for T2D, but was not associated with undernutrition.
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نویسندگان مقاله | Maja Vukovi&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Milo&#x161; Maksimovi&#x107;
1. Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina 2. Institute of Hygiene and Medical Ecology, Faculty of Medicine, University of Belgrade, Belgrade, Serbia


| Sini&#x161;a Risti&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Milan Kuli&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Biljana Mijovi&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Marija Mili&#x107;
Faculty of Medicine, University of Pristina Temporarily Settled in Kosovska Mitrovica, Kosovska Mitrovica, Serbia


| Nenad Lalovi&#x107;
1. Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina 2. University Hospital Fo&#x10D;a, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Nikolina Elez-Burnjakovi&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Danijela Radulovi&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Dajana Nogo-&#x17D;ivanovi&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Ljiljana Krsmanovi&#x107;
1. Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina 2. University Hospital Fo&#x10D;a, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Nada Avram
1. Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina 2. University Hospital Fo&#x10D;a, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Biljana Milinkovi&#x107;
1. Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina 2. University Hospital Fo&#x10D;a, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Sini&#x161;a &#x160;olaja
1. Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina 2. University Hospital Fo&#x10D;a, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Sandra Matovi&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Jovan Kuli&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina


| Bojan Joksimovi&#x107;
Faculty of Medicine Fo&#x10D;a, University of East Sarajevo, Fo&#x10D;a, Republic of Srpska, Bosnia and Herzegovina
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/37081
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