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Research in Pharmaceutical Sciences، جلد ۲۰، شماره ۱، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Development and evaluation of Sahasthara Thai medicine remedy in a film-forming spray for topical anti-inflammatory therapy |
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| چکیده انگلیسی مقاله |
Background and purpose : The study aimed to develop a localized topical anti-inflammatory treatment using a Thai medicinal herbal remedy called "Sahasthara," known for its anti-inflammatory properties, to create a film-forming spray (FFS). Experimental approach : This research evaluated and developed an FFS formulated with Sahasthara ethanolic extract (SHTe). Subsequently, the optimized formulation was investigated for in vitro anti-inflammatory activity, cell culture toxicity assessment, pharmacological effects, and stability studies. Findings / Results : An optimized formulation (F12) was identified, consisting of 1% w/w SHTe and PVP K90, glycerol, PEG 400, sesame oil, a eutectic blend, and ethanol. This clear, smooth surface, yellowish film releases 42.37%, 38.67%, and 68.93% at 8 h, corresponding to a flux of 20.94, 1.92, and 26.32 µg/cm 2 /h of piperine, plumbagin, and β-asarone, respectively. F12 was determined to have a viscosity, drying time, and spray angle of 20 cps, 4.57 min, and 66.0 degrees. In-vitro anti-inflammatory activity demonstrated nitric oxide (NO) inhibition with an IC 50 of 9.18 µg/mL. No apparent toxicity was observed in a skin cell line. This formulation was developed to be physically stable after undergoing freeze-thaw cycles. Although thermodynamic stability studies under accelerated conditions revealed a minor decrease in piperine and β-asarone within the film, the results indicate no statistically significant changes in its anti-inflammatory activity. Conclusion and implications : SHTe FFS offers optimal spray ability, a high in-vitro drug release profile, potent inhibition of anti-inflammatory markers, and stability under accelerated conditions. These findings suggest that SHTe FFS can serve as an innovative topical anti-inflammatory treatment. |
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| کلیدواژه‌های انگلیسی مقاله |
Anti-inflammatory,Drug release,Film-forming spray,Sahasthara,Stability study,Topical drug. |
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| نویسندگان مقاله |
| Ninnart Intharit
Department of Applied Thai Traditional Medicine and Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Khlong Luang, Pathum Thani, 12120, Thailand.
| Arunporn Itharat
Department of Applied Thai Traditional Medicine and Center of Excellence in Applied Thai Traditional Medicine Research (CEATMR), Faculty of Medicine, Thammasat University, Khlong Luang, Pathum Thani, 12120, Thailand.
| Chadchom Choockong
Regional Medical Science Center 12 Songkhla, Department of Medical Sciences, Songkhla 90100, Thailand.
| Weerachai Pipatrattanaseree
Department of Pharmaceutical Technology, Faculty of Pharmaceutical Sciences, Prince of Songkhla University, Songkhla 90112, Thailand.
| Wichan Ketjinda
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2P5, Canada.
| Neal M. Davies
Faculty of Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, AB T6G 2P5, Canada.
| Raimar Löbenberg
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| نشانی اینترنتی |
http://rps.mui.ac.ir/index.php/jrps/article/view/2290 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
Original Article |
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