|
|
Middle East Journal of Cancer، جلد ۱۶، شماره ۲، صفحات ۱۸۱-۱۸۸
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Stromal Cell-Derived Factor1 Genetic Variation at Locus 801 in Patients with Endometrial Cancer |
|
| چکیده انگلیسی مقاله |
Background: The gene's 3′ untranslated region of stromal cell-derived factor1 (SDF-1/ CXC chemokine ligand 12 (CXCL12)) contains a polymorphism, known as SDF1-3′A at location 801, and has been linked to various types of cancers. The present study aimed to evaluate the relationship between this polymorphism and genetic predisposition to endometrial cancer.
Method: In this case-control study, DNA was extracted from blood samples of 108 endometrial cancer patients and 123 healthy individuals through salting out method. Genotyping was done by restriction fragment length polymorphism-polymerase chain reaction method, and the data were analyzed using chi-square test.
Results: A total number of 67 (62%) patients emerged as GG genotypes, 35 (32.4%) with GA, and 6 (5.6%) with AA genotypes. The frequency of GG, GA and AA in healthy control group was found to be 68 (55.3%), 50 (40.6%) and 5 (4.1%), respectively. Furthermore, the most frequent allele in both patient (169 (78.25%)) and control (186 (75.6%)) groups was G allele. However, no significant difference was observed between genotypes and alleles frequencies between the two groups. Furthermore, no significant association was observed between genotypes distribution and menopausal status (P = 0.70), tumor size (P = 0.62), degree of tumor differentiation (P = 0.74), stage (P = 0.35), tumor type (P = 0.22), and myometrial invasion (P = 0.22).
Conclusion: Our results show that SDF1-3′A at location 801 may not enhance the risk of endometrial cancer. However, further research with a larger sample size is required to understand the molecular behavior of the SDF-1 gene polymorphism in endometrial cancer. |
|
| کلیدواژه‌های انگلیسی مقاله |
Endometrial neoplasms,Stromal cell-derived factor1,Chemokine CXCL12,Genotype |
|
| نویسندگان مقاله |
Fateme Sadat Najib |
Obstetrics and Gynecology Department, Infertility Research Center, Shiraz University of Medical Sciences, Shiraz, Iran
Elham Izanloo |
Obstetrics and Gynecology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Maryam Aghdaki |
Obstetrics and Gynecology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Soolmaz Khansalar |
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Javad Fattahi |
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
Zahra Oveisi |
Obstetrics and Gynecology Department, Shiraz University of Medical Sciences, Shiraz, Iran
Mohammad Reza Haghshenas |
Shiraz Institute for Cancer Research, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
|
|
| نشانی اینترنتی |
https://mejc.sums.ac.ir/article_50278_ad26ca391c98ff7cff38b877ae2ba977.pdf |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|