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Iranian Heart Journal، جلد ۲۶، شماره ۲، صفحات ۲۳-۳۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Elevated Arterial Lactate as a Predictor of Contrast-Induced Nephropathy following Percutaneous Coronary Intervention |
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| چکیده انگلیسی مقاله |
Background: The incidence of contrast-induced nephropathy (CIN) varies from 0% to 24%. Its mechanism is multifactorial and still not yet fully understood. In our study, we aimed to evaluate the role of elevated arterial lactate as a predictor of CIN following percutaneous coronary intervention (PCI) in diabetic patients with acute coronary syndrome (ACS). Methods: This prospective study enrolled 200 diabetic patients with ACS who underwent PCI. Patients with hemodynamic instability, renal impairment, or recent contrast exposure were excluded. Arterial lactate was measured on admission and serum creatinine at 0 and 72 hours. CIN was defined as a rise in serum creatinine of at least 0.5 mg/dL or a 25% increase from baseline within 48–72 hours after contrast exposure. Results: The mean age was 60 ± 10.34 years, 64% were males, and 33% developed CIN (n = 66). Higher arterial lactate was directly proportional to CIN development (P < 0.001). Other predictors were the heart failure signs, procedure duration, and contrast volume >100 mL. In multivariate regression, the most significant predictors were preprocedural arterial lactate > 1 mmol/L (OR 3.932, 95% CI 1.765 to 8.759; P = 0.001) and procedure duration > 69 minutes (OR 4.180, 95% CI 1.884 to 9.272; P < 0.001). Conclusions: Preprocedural arterial lactate >1 mmol/L, and procedure duration > 69 minutes were the most important predictors of CIN in diabetic patients with ACS who underwent PCI. Other risk factors were heart failure signs and contrast volume > 100 mL. (Iranian Heart Journal 2025; 26(2): 23-32) |
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| کلیدواژه‌های انگلیسی مقاله |
Contrast-induced nephropathy,Arterial lactate,Percutaneous Coronary Intervention,Acute coronary syndrome |
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| نویسندگان مقاله |
Mahmoud Baraka |
Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed Shawky Elserafy |
Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed Shokry |
Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
Ahmed Elshazly |
Cardiology Department, Faculty of Medicine, Ain Shams University, Cairo, Egypt.
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| نشانی اینترنتی |
https://journal.iha.org.ir/article_217907_93d0d15af60da80d32eedbeabf734033.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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