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Iranian Heart Journal، جلد ۲۶، شماره ۲، صفحات ۶-۱۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Impact of Reducing Intervals Between Two Cardioplegia Injections on Clinical Outcomes Among Pediatrics Undergoing Cardiopulmonary Bypass: A Randomized Clinical Trial |
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| چکیده انگلیسی مقاله |
Background: The use of a cardiopulmonary bypass machine during heart surgery can increase the risk of myocardial damage, as indicated by elevated levels of troponin I and creatine phosphokinase markers. Therefore, there is a need to reduce ischemia-reperfusion injury following pediatric cardiopulmonary bypass surgery. It appears that myocardial damage may be mitigated by shortening the intervals between cardioplegia injections. Methods: This randomized controlled trial was conducted on pediatric patients undergoing surgery for Tetralogy of Fallot. Participants were randomly assigned to either an intervention group or a control group using the block randomization method. In the intervention group, the interval between 2 doses of Del Nido cardioplegia was reduced to 40 minutes, while patients in the control group received Del Nido cardioplegia every 60 minutes. Data for the trial were collected using checklists prepared by the researcher. Results: The study findings indicated that, although the mean levels of troponin and phosphokinase were significantly lower in the trial group compared with the control group, the changes in both markers across different measurement times were similar in both groups. Most other clinical outcome parameters of heart surgeries, such as left ventricular ejection fraction, the time required for the heart rhythm to return to normal after aortic declamping, and the type of arrhythmia, did not show significant differences between the trial groups. Conclusions: The findings of our trial demonstrated that, although there were no statistically significant changes in hemodynamic status, left ventricular ejection fraction, blood urea nitrogen, creatinine levels, inotropic score, time for heart rhythm resumption, and frequency of arrhythmia, reducing the interval between 2 Del Nido injections had positive effects on myocardial protection in pediatric heart surgeries. (Iranian Heart Journal 2025; 26(2): 6-14) |
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| کلیدواژه‌های انگلیسی مقاله |
Cardioplegia,clinical outcome,pediatric patients,TETRALOGY OF FALLOT |
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| نویسندگان مقاله |
Amirhossein Jalali |
Rajaie Cardiovascular Institute, Iran University of Medical Sciences, Tehran, IR Iran.
Maziar Gholampour Dehaki |
Rajaie Cardiovascular Institute, Iran University of Medical Sciences, Tehran, IR Iran.
Yalda Asheghi |
Rajaie Cardiovascular Institute, Iran University of Medical Sciences, Tehran, IR Iran.
Naser Kachoueian |
Shahid Beheshti University of Medical Sciences, Tehran, IR Iran.
Alireza Yaghoubi |
Rajaie Cardiovascular Institute, Iran University of Medical Sciences, Tehran, IR Iran.
Soha Sadeghpour |
Nilou Medical Laboratory, Tehran, IR Iran.
Farshad Jalili Shahandashti |
Rajaie Cardiovascular Institute, Iran University of Medical Sciences, Tehran, IR Iran.
Zahra Serajpour |
Nilou Medical Laboratory, Tehran, IR Iran.
Farhad Gorjipour |
Rajaie Cardiovascular Institute, Iran University of Medical Sciences, Tehran, IR Iran.
Fazel Gorjipour |
Iran University of Medical Sciences, Tehran, IR Iran.
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| نشانی اینترنتی |
https://journal.iha.org.ir/article_217904_90a0251583c34c2e670b9d047fcbc5b9.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
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