این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۲۳، شماره ۹۲، صفحات ۷۲-۸۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Evaluation analgesic and anti-inflammatory effects of Rosa×damascena Herrm. fixed oil (Persian medicine preparation)
چکیده انگلیسی مقاله
Background: Historical medical and pharmacological manuscripts describe various pharmaceutical applications of medieval Persian medicine. One of the known forms of application for therapeutic purposes via topical or systemic administration is herbal oils. “Rose fixed oil” (Rosa×damascena Herrm.) has traditional applications in the management of inflammation and pain due to ailment conditions such as inflammatory bowel disease, hemorrhoid, earache, and gastro-esophageal reflux diseases topically or orally. Objective: This study evaluated mechanism of analgesic and anti-inflammatory effects of “Rose fixed oil” by animal models. Methods: 50 grams of dried powdered petals of R.×damascena were weighed and soaked with 800ml distilled water for 24 hours. The mixture was heated for 70 minutes. Writhing, Tail flick, Hot plate, and carrageenan tests were used for the evaluation of the anti-inflammatory and analgesic effects of rose oil. The level of TNF-α and MPO activity in serum was measured. Results: “Rose fixed oil” 400mg/kg in all tests have been shown a significant effect. “Rose fixed oil” could decrease TNF-α and MPO. Previous studies demonstrated Rose extract can inhibit inflammation in animal models and clinical trials. “Rose fixed oil” in some studies has been shown an anti-inflammatory effect. The results of this study confirmed anti-inflammatory and analgesic effects of “Rose fixed oil” as a Persian medicine preparation. Conclusion: The main finding of this study was that “Rose fixed oil” as a Persian medicine preparation, possesses analgesic and anti-inflammatory effects through peripheral and central analgesic activity, and modulation of acute and chronic inflammation mediators in a dose-dependent manner.
کلیدواژه‌های انگلیسی مقاله Rose oil, Rosa×damascena, Inflammation, Anti-nociceptive, Tail flick, Hot plate
نویسندگان مقاله | Samane Jahanabadi
Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Pharmaceutical Science Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran


| Erfaneh Akhavanfarid
School of Pharmacy, Shahid Sadoughi University of Medical Science Health Services, Yazd, Iran


| Hamed Mahmoodian
Management Department, Meybod University, Meybod, Iran


| Mobina Ghiasirad
School of Pharmacy, Shahid Sadoughi University of Medical Science Health Services, Yazd, Iran


| Rahele Zareshahi
Department of Pharmacognosy, School of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran; Herbal Medicines Research Center, School of Pharmacy, Shahid Sadoughi University of Medical Science Health Services, Yazd, Iran
نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-681-1&slc_lang=en&sid=1
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده داروسازی سنتی و طب سنتی
نوع مقاله منتشر شده پژوهشی
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات