| چکیده انگلیسی مقاله |
Background: Idiopathic granulomatous mastitis (IGM) is a chronic breast disease with unknown pathophysiological and clinical aspects. Therefore, we designed this multi-center prospective case-control study to explore and clarify the risk factors with an acceptable sample size. Methods: From March 2021 to December 2023, five hundred-four women with a histologically proven IGM were entered into the IGM group and 504 women with healthy breasts were included in the control group across nine centers. Participants' information was obtained by trained staff. Multivariate binary logistic regression was used to estimate the odds ratio (OR) and 95% confidence intervals (CI) for the associations between variables and IGM. Results: The mean age of all participants was 34.92 ± 7.12 yr. The previous history of diseases as a whole, was significantly higher in the IGM group (33.1%) compared with the control group (26.6%). Logistic regression showed that previous lactation (OR= 7.51, 95% CI= 2.37-23.77) and a positive history of diabetes (OR = 4.23, 95% CI= 1.32-13.51) had a positive association with IGM, while OCP use (OR = 0.70, 95% CI= 0.52-0.93) was associated with IGM reversely. Conclusion: The history of breastfeeding and not its duration is associated with a 7-fold increase in the rate of IGM. Furthermore, previous history of diabetes is a risk factor, while OCP use is a protective factor against IGM. We are designing another study to further investigate the relationship between breastfeeding, milk stasis, and IGM, based on our findings. |
| نویسندگان مقاله |
| Sadaf Alipour
1. Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Surgery, Arash Women’s Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Maryam Tabatabaeian
Anahid Clinic, Isfahan, Iran
| Parisa Aziminezhadan
Aziminezhadan Breast Clinic, Tehran, Iran
| Azin Saberi
Department of Surgery, Arash Women’s Hospital, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran
| Maryam Daneshpazhooh
1. Autoimmune Bullous Diseases Research Center, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Dermatology, Razi Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Ramesh Omranipour
1. Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
| Paniz Famil-Amir
Aziminezhadan Breast Clinic, Tehran, Iran
| Najmeh Ahmadi
Anahid Clinic, Isfahan, Iran
| Maryam Sarkardeh
1. Department of Surgical Oncology, Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran 2. Department of Surgery, Imam Reza Hospital, Mashhad University of Medical Sciences, Mashhad, Iran
| Nahid Nafissi
Clinical Research Development Center (RCRDC), Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
| Azita Mazinani
Clinical Research Development Center (RCRDC), Rasoul Akram Hospital, Iran University of Medical Sciences, Tehran, Iran
| Azadeh Joulaee
Department of Surgery, Shahid Beheshti University of Medical Sciences, Tehran, Iran
| Shahla Astaraki
Anahid Clinic, Isfahan, Iran
| Zohreh Zahernia-Shahrbabaki
Anahid Clinic, Isfahan, Iran
| Reihane Tahery-Mehr
Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
| Maryam Gharini-Ahmadi
Department of Nursing, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Behnaz Khajeh-Ali-Beiki
Department of Nursing, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Marzieh Orouji
Department of Nursing, Arash Women’s Hospital, Tehran University of Medical Sciences, Tehran, Iran
| Bita Eslami
Breast Diseases Research Center (BDRC), Cancer Institute, Tehran University of Medical Sciences, Tehran, Iran
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