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Archives of Anesthesiology and Critical Care، جلد ۱۱، شماره ۲، صفحات ۲۵۶-۲۵۸
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Massive Gastrointestinal Bleeding, Consequences Interactions of Apixaban, Diltiazem and Aspirin: Case Report |
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| چکیده انگلیسی مقاله |
Anticoagulation is the cornerstone of preventing thrombosis. Following the aging of society and the greater use of anticoagulant drugs, we see more serious complications in this group. The reduced occurrence of significant bleeding represents a notable benefit of direct oral anticoagulants (DOACs) in comparison to vitamin K antagonists. However, the unavailability of Andexanet alfa and Idarucizumab complicates the management of bleeding associated with DOACs. This case describes a 69-year-old man who presented with massive gastrointestinal bleeding, hemorrhagic shock, and loss of conciseness. He has been taking apixaban 2.5 mg twice a day, aspirin 80 mg once a day, and diltiazem 60 mg three times daily. Bleeding was controlled through transfusion of two units of fresh frozen plasma, five units of packed cell, four units of platelet, and tranexamic acid injection. Although hemorrhagic shock was successfully managed, he unfortunately passed away after three weeks of hospitalization following Ventilator-associated pneumonia and sepsis. In this case, we discuss the importance of the drug interaction of apixaban, diltiazem, and aspirin. |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
| Hossein Karballaei Mirzahosseini
Department of Clinical Pharmacy, School of Pharmacy, Semnan University of Medical Sciences, Semnan, Iran.
| Parinaz Shahriari
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
| Ehsan Yousefi-Mazhin
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran.
| Atabak Najafi
Department of Anesthesiology and Critical Care Medicine, Sina Hospital, Tehran University of Medical Sciences, Tehran, Iran.
| Amirmahdi Mojtahedzadeh
Faculty of Medicine, Semmelweis University, Budapest, Hungary.
| Mojtaba Mojtahedzadeh
Department of Clinical Pharmacy, School of Pharmacy, Tehran University of Medical Sciences, Tehran, Iran. & Pharmaceutical Research Center, Tehran University of Medical Sciences, Tehran, Iran.
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| نشانی اینترنتی |
https://aacc.tums.ac.ir/index.php/aacc/article/view/1016 |
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