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Archives of Breast Cancer، جلد ۱۲، شماره ۱، صفحات ۳۱-۳۷
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عنوان انگلیسی The Role of Long Non-coding RNA (NKILA and LINC00993) as Tumour Biomarkers in Breast Cancer : Role of Long Non-coding RNA
چکیده انگلیسی مقاله Background: Long non-coding RNAs (NKILA and LINC00993) are downregulated in breast cancer (BC) and can have potential use as a novel tumor biomarker. The Aim of the work is to investigate the LncRNAs (NKILA and LINC00993) and cytokines (NF-κB and CXCL-1) as potential biomarkers in BC.  Methods: This Cross-sectional study included sixty-four pairs of surgically resected human breast cancer tissues and adjacent breast tissues. Expressions of LncRNAs (NKILA, LINC00993) and (NF-κB, CXCL1) cytokines were detected using real-time quantitative polymerase chain reaction (qPCR) analysis, Results: There was a significant decrease in LncRNAs (NKILA, LINC00993) levels in tumor tissue compared to normal tissue (P<0.001). Also, there was a significant increase in NF-κB and CXCL1 levels in tumor tissue compared to normal tissue (P<0.001). ROC curve analysis indicated that the LncRNAs (NKILA, LINC00993) expression levels could be considered a promising marker for the diagnosis of breast cancer patients with a sensitivity (90.6%, 92.2% respectively). Also, cytokines (NF-κB and CXCL-1) expression levels could be considered a promising marker for the diagnosis of breast cancer patients with a sensitivity and specificity of 87.5%, and 89.1% respectively). Conclusion: These findings suggest that LncRNAs (NKILA, LINC00993) and cytokines (NF-κB and CXCL-1) can be used as novel biomarkers for breast cancer.
کلیدواژه‌های انگلیسی مقاله Biomarker, NKILA, LINC00993, breast cancer
نویسندگان مقاله | Randa H. Mohamed
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt


| Mohamed M. Alkilany
General Surgery Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt


| Hoda K. El-feky
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt


| Bassel T. Abd-elmoneim
General Practitioner, Faculty of Medicine, Ain Shams University, Cairo, Egypt


| Amal F Abd-Elmageed
Medical Biochemistry Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/990
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کد مقاله (doi) 10.32768/abc.202512131-37
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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