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Archives of Breast Cancer، جلد ۱۲، شماره ۱، صفحات ۱۰۵-۱۱۳
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عنوان انگلیسی The Role of Apparent Diffusion Coefficient (ADC) in Differentiating Between Benign and Malignant Breast Lesions in a Sample of Iranian Women: Diffusion weighted in breast MRI
چکیده انگلیسی مقاله Background: Breast cancer is the most prevalent cancer among women, emphasizing the need for early detection and accurate diagnosis. This study investigates the role of the Apparent Diffusion Coefficient (ADC) in distinguishing between benign and malignant breast lesions using Magnetic Resonance Imaging (MRI) and Diffusion-Weighted Imaging (DWI). A retrospective cross-sectional study was conducted involving 96 patients with breast lesions who underwent MRI and DWI scans. Methods: Patients were selected from among those who had MRI and DWI scans with b-values of 0, 800, and 1000 s/mm². ADC values were calculated by plotting the Region of Interest (ROI) and extracting corresponding values. Histological evaluations confirmed the diagnosis of the lesions. Statistical analyses included calculating accuracy, sensitivity, and specificity, along with Receiver Operating Characteristic (ROC) curve analysis to determine the optimal cut-off value. Results: The ADC values demonstrated an accuracy of 92.5%, sensitivity of 93.2%, and specificity of 91.2% in differentiating between benign and malignant lesions. The ROC curve analysis established a cut-off value of 1.44 × 10⁻³ mm²/s for effective differentiation. Conclusion: ADC values can serve as a reliable biomarker for distinguishing breast lesions, potentially reducing unnecessary biopsies for benign cases and aiding clinicians in treatment decisions. The integration of ADC measurements into clinical practice could enhance patient management in breast cancer. Further research is warranted to validate these findings and explore additional markers to improve diagnostic accuracy in breast cancer management.
کلیدواژه‌های انگلیسی مقاله MRI, Diffusion, Apparent diffusion coefficient (ADC), Benign breast lesions, Breast Cancer
نویسندگان مقاله | Zubin Souri
Radiology Department, School of Medicine, Poursina Hospital, Guilan University of Medical Sciences, Rasht, Iran


| Pejman Kiani
Associated Professor, Radiology Department, School of Medicine, Guilan University of Medical Sciences, Rasht, Iran
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/1050
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi) 10.32768/abc.2025121105-113
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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