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Archives of Breast Cancer، جلد ۱۲، شماره ۱، صفحات ۴۷-۵۴
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چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Regulation of the Inflammatory Profile of Blood Serum in Human Breast Cancer: Prominent Roles for TNF-alpha and RPR Pathways on Breast Surgery: Inflammatory profile in human breast cancer
چکیده انگلیسی مقاله Background: The objective of this study is to compare the effects between the combination of PECS Block II with GA and GA alone on the inflammation levels in breast cancer, measure by Tumor Necrosis Factor-Alpha (TNF-α) and the red blood cell distribution width to platelet ratio (RPR). Methods: Experimental analytical study with parallel randomized control trial was done in 48 breast cancer patients who underwent breast removal surgery at Dr. Kariadi Hospital between  August – October 2023. Patients were randomly allocated into 2 groups, control (GA only) and treatment (PECS Block II + GA). Demographic data were obtained preoperatively, blood samples were collected 24 hours before and after surgery. TNF-α levels were analyzed using enzyme-linked immunosorbant assay (ELISA), while RPR were obtained from complete blood count. Independent t and mann-whitney tests were used, with a p-value <0,05 was considered significant. Results: Postoperative TNF-α levels were similar in both groups (8.15 ± 5.31 vs 6.21 ± 5.58; p=0,135), but the difference between TNF-α levels was significantly higher in treatment group (-5.08 ± 3.70; p = 0.001). Postoperative RPR levels were higher in control group than treatment group (0,64 ± 0,28 vs 0,50 ± 0,20; p=0,031), where the difference between RPR levels was higher in treatment group (-0,07 ± 0,19; p = 0,037). Conclusion: Inflammatory biomarkers, in the form of TNF-α and RPR in breast cancer surgery were found to be lower with the usage of the combination of PECS Block II with general anesthesia than with general anesthesia only.
کلیدواژه‌های انگلیسی مقاله breast cancer, TNF-α, RPR, general anesthesia, PECS Block II
نویسندگان مقاله | Ahmad Za&apos;im Muhtar Mahfuddin
Department of General Surgery, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia


| Yan Wisnu Prajoko
Department of Oncology Surgery, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia


| Mohamad Sofyan Harahap
Department of Anesthesiology, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia


| Banundari Rachmawati
Department of Clinical Pathology, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia


| Widya Istanto Nurcahyo
Department of Anesthesiology, Dr. Kariadi Hospital-Diponegoro University, Semarang, Indonesia
نشانی اینترنتی https://archbreastcancer.com/index.php/abc/article/view/1012
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کد مقاله (doi) 10.32768/abc.202512147-54
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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