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Tanaffos، جلد ۲۳، شماره ۲، صفحات ۱۸۳-۱۸۸
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عنوان انگلیسی Variation of Immunoglobulin M and Immunoglobulin G Serum Levels in Seropositive COVID-19 Patients in Mazandaran, Iran: A Six-Month Investigation
چکیده انگلیسی مقاله Background: Forecasting the longevity of patients' immune stability could be the most effective approach to preventing illnesses. This study investigates immunoglobulin M (IgM) serum longevity, immunoglobulin G (IgG), and corresponding risk factors in the first phase seropositive patients in Mazandaran, Iran. Materials and Methods: This descriptive cross-sectional study aimed to assess IgM and IgG serum levels in a cohort of 184 seropositive patients during six months. The data analysis involved various statistical methods including descriptive statistics, the chi-square test, independent and paired t-tests, and single and multivariate logistic regression. Results: A total of 103 (56%) patients lacked the necessary antibodies, whereas 81 (44%) remained seropositive. According to the results of multivariable logistic regression, patients with a travel history, hospital admissions, and end-stage renal disease (ESRD) had 3.24 (P=0.04), 12.63 (P=0.018), and 9.79 (P=0.001) times higher chances of stable seropositivity, respectively. The average IgG and IgM serum levels fell by 4.5 and 3 units, respectively (P<0.001). In addition, serum levels of IgM and IgG increased by 12% and 12.5%, respectively, and dropped by 75.5% in both serums. There was no increase in either serum level for any of the patients. Conclusion: The duration of immune serum stability in patients can significantly reduce disease mortality. The concurrent detection of IgM and IgG antibodies also assists in identifying the infectious stage.
کلیدواژه‌های انگلیسی مقاله COVID-19,IgG,IgM,serology
نویسندگان مقاله Seyed Abbas Mousavi |
Psychiatry and Behavioral Sciences Research Center, Institute of Addiction, Department of Psychiatry, Mazandaran University of Medical Sciences, Sari, Iran

Faezeh Sadat Movahedi |
Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

Fatemeh Safari Hajikalai |
Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

Jamshid Yazdani Charati |
Department of Biostatistics, Health Sciences Research Center, Institute of Addiction, Mazandaran University of Medical Sciences, Sari, Iran

Abolghasem Ajami |
Department of Immunology, School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran

Seyed Mohsen Soleimani |
Deputy of Health, Mazandaran University of Medical Sciences, Sari, Iran

Zainab Bandalizadeh |
Health Department, Mazandaran University of Medical Sciences, Sari, Iran.

Saeed Kaviani Charati |
Department of Biostatistics, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran

نشانی اینترنتی https://www.tanaffosjournal.ir/article_720279_f1d8133d640f6909e094935dc9084ef4.pdf
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