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Iranian Journal of Neonatology، جلد ۱۶، شماره ۱، صفحات ۴۰-۴۷
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Comparison of Caffeine and Aminophylline in Treating Apnea of Prematurity with Historical Data: A Single Center, Observational Study in Taiwan |
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| چکیده انگلیسی مقاله |
Background: For treatment of apnea of prematurity (AOP), aminophylline is the first line medication in Taiwan. There are limited trials in Taiwan regarding the therapeutic benefits and adverse effects of caffeine for the treatment of AOP.Methods: This observational study conducted between January 2018 and December 2018 investigated the clinical effectiveness and safety of caffeine for AOP in the neonatal intensive care unit (NICU) at a hospital in Taiwan. Very preterm neonates with very low birth weight and apnea were treated with a loading dose of caffeine citrate at 20 mg/kg, followed by a 5–10 mg/kg maintenance dose every 24 h. Preterm infants admitted to the NICU between January 2017 and December 2018 and treated with aminophylline/theophylline were included for comparison.Results: Seventeen infants receiving caffeine therapy and 43 receiving aminophylline/theophylline therapy were enrolled in this study. Although fewer apneic spells were observed from the second week of commencing caffeine treatment (P=0.028), the mean duration of apnea and episodes of apneic spells during the first four weeks of treatment were similar between the two groups. There were no significant differences in short-term side effects, duration of intubation, noninvasive respiratory support, hospitalization, and medical expenses between the two groups.Conclusion: Caffeine treatment can reduce the frequency of apnea after one week of administration; however, both caffeine and aminophylline/theophylline showed similar effects in treating AOP. |
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| کلیدواژه‌های انگلیسی مقاله |
apnea of prematurity, Caffeine, methylxanthine, Preterm |
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| نویسندگان مقاله |
| Fong-Cheng Ho
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
| Tsai-Hui Duh
Department of Medicinal and Applied Chemistry, Kaohsiung Medical University, Kaohsiung 80708, Taiwan
| Hao-Wei Chung
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
| Shu-Ting Yang
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
| Hsiu-Lin Chen
Department of Pediatrics, Kaohsiung Medical University Hospital, Kaohsiung Medical University, Kaohsiung 80756, Taiwan
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| نشانی اینترنتی |
https://ijn.mums.ac.ir/article_25047.html |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
تحقیقی اصیل |
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