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International journal of Advanced Biological and Biomedical Research، جلد ۱۳، شماره ۲، صفحات ۱۲۹-۱۴۴
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Recent Discoveries and Clinical Applications of Deoxyribonucleic Acid (DNA) Methylation Inhibitors in the Diagnosis, Classification, and Treatment of Meningiomas |
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| چکیده انگلیسی مقاله |
Recent advancements in molecular biology and genomics have revolutionized our understanding of meningiomas, leading to novel diagnostic and treatment strategies. Meningiomas are common central nervous system tumors and their management has traditionally relied on histopathological classification. However, the integration of DNA methylation analysis has provided new understanding into the molecular activities of these tumors, providing potential biomarkers for personalized medicine. This review involved a comprehensive search of electronic databases (e.g., PubMed, Web of Science, and Scopus) was conducted to identify relevant studies based on keywords related to DNA methylation inhibitors, meningioma, diagnosis, classification, and treatment. This study was aimed at assessing the recent discoveries regarding DNA methylation inhibitors and their potential clinical applications in diagnosing, classifying, and treating meningiomas. DNA methylation inhibitors are applied in modulating gene expression patterns in meningiomas and Nucleoside analogs demonstrated potential in inhibiting meningioma cell growth by inducing apoptosis through DNA hypomethylation. These inhibitors, when used in combination with conventional treatments, could enhance treatment efficacy, overcome drug resistance, and reduce tumor recurrence, as they can be specifically used to target specific molecular subtypes of meningiomas. |
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| کلیدواژه‌های انگلیسی مقاله |
DNA methylation inhibitor,Meningioma,Biomarkers,Treatment Strategies |
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| نویسندگان مقاله |
Inusah Abdul-Hanan Saani |
University for Development Studies, Ghana
Ahorlu Elim |
University for Development Studies, Ghana
Ziblim Andrew |
University for Development Studies, Ghana
Gbayisomore Tolulope Judah |
University of Benin Teaching hospital, Edo state, Nigeria
Omiyale Olumakinde Charles |
Department of Pharmacology, Toxicology and Therapeutics, Faculty of Basic Medical Sciences, College of Medicine, University of Lagos, Nigeria
Ike-Okpe Onyekachi |
Enugu State University of Science and Technology, Nigeria
Ajayi Rufus |
University of Illinois at Spingfield, Springfield, Illinois, USA
Nketsiah Esther |
Clinical Rehabilitation Division, Nyaho Medical Centre, Accra, Ghana
Ayeni Lucky Aighowmafe |
University of Wolverhampton, USA
Obe Feranmi Emmanuel |
Department of Medical Laboratory Science, Ladoke Akintola University of Technology Ogbomoso, Nigeria
Alimi Kehinde Hikmat |
Nigerian Institute of Medical Research, Lagos, Nigeria
Babalola Isaac Olamide |
Ladoke Akintola University of Technology, Nigeria
Abimbola Esther Atinuke |
Department of Biochemistry, Bayero University Kano, Nigeria
Ologbonjaye Kehinde |
Department of Ecology and Evolutionary Biology, Tulane University, New Orleans Louisiana, Nigeria
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| نشانی اینترنتی |
https://www.ijabbr.com/article_716492_ddfee03df3fbcdb8e87b0ce0946bc929.pdf |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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