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Iranian Journal of Public Health، جلد ۵۳، شماره ۱۲، صفحات ۲۷۸۹-۲۸۰۱
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عنوان انگلیسی Identification of CD8+ Immunogenic Peptides for Vaccine Design against Nipah Virus in Humans
چکیده انگلیسی مقاله Background: Nipah virus is a pathogenic virus of ruinous zoonotic potential with inflated rate of mortality in humans. Methods: Considering the emerging threat of this pandemic virus, the present investigation amid to design vaccine by using the bioinformatics tools such as host and virus codon usage analysis, CD8+ peptide prediction, immunogenicity/allergenicity/toxicity, MHC-I allele binding prediction and subsequent population coverage and MHC-I-peptide docking analysis. Results: In this study (conducted in 2022 at School of Biotechnology, Katra, India), a set of 11 peptides of the structural proteins of Nipah Virus were predicted and recognized by the set of MHC-I alleles that are expressed in 92% of the global human population. Conclusion: The strong interactions between these peptides and the MHC-I protein suggest them as strong peptide candidates for the development of vaccine against Nipah Virus.
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نویسندگان مقاله | Pankaj Suden
School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India


| Inderpal Singh
School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India


| Chitrakshi Chopra
School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India


| Malvika Mehta
School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India


| Ratna Chandra
School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India


| Indu Bhushan
School of Biotechnology, Shri Mata Vaishno Devi University, Katra, India
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/33645
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