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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۱۳۵-۱۳۵
عنوان فارسی P۸۵: Spreading Depression in the Brain Cortex and Spinal Cord
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P85: Spreading Depression in the Brain Cortex and Spinal Cord
چکیده انگلیسی مقاله Cortical spreading depression (CSD) has been suggested to underlie some neurological disorders such as migraine. Despite the intensity with which many investigators have studied SD in the brain, only a few studies have aimed to identify SD in the spinal cord. Here we described the main characteristic features of SD in the spinal cord induced by different methods including various spinal cord injury models and demonstrated that SD enhances the spinal cord activity following a transient suppressive period. These findings suggest that SD may play a role in the mechanisms of spinal neurogenic shock, spinal cord injury, and pain. Furthermore, we studied the effect of CSD on the neuronal activity of the spinal cord. CSD was induced via cortical pinprick injury or KCl injection in the somatosensory cortex. CSD did not propagate into the cervical spinal cord. However, intracellular recordings of the neurons in the dorsal horn of C2 segment, ipsilateral to the hemisphere in which CSD was evoked, showed a transient suppression of spontaneous burst discharges, followed by a significant enhancement of the neuronal activity. This indicates a link between a putative cause of the neurological symptoms and the subsequent pain of migraine.
کلیدواژه‌های انگلیسی مقاله Cortical Spreading Depression, KCL, Spinal Cord Injury
نویسندگان مقاله احمدعلی لطفی نیا | ahmad ali lotfinia
shefa neuroscience research, khatam alanbia hospital, tehran, iran.


میلاد احمدی | milad ahmadi
shefa neuroscience research, khatam alanbia hospital, tehran, iran.


بابک خدایی | babak khodaie
shefa neuroscience research, khatam alanbia hospital, tehran, iran.


محمود لطفی نیا | mahmoud lotfinia
shefa neuroscience research, khatam alanbia hospital, tehran, iran.


علی گرجی | ali gorji
shefa neuroscience research, khatam alanbia hospital, tehran, iran.
نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-484&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332332.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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