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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۹۹-۹۹
عنوان فارسی P۴۹: The Role of Extra Cellular Matrix in Brain Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P49: The Role of Extra Cellular Matrix in Brain Injury
چکیده انگلیسی مقاله Traumatic brain injury (TBI) results from a sudden and external physical impact to the head, and often leads to motor and cognitive impairment. Using tissue engineering strategies, we aimed to review aspects of extra cellular matrix (ECM) based scaffold that could be delivered to the injured brain. The ECM is produced intracellularly and secreted to form a dense network of proteins and glycans, occupying the parenchyma of virtually all cells. It is a source of diverse molecular signals that guide cellular growth, activity and survival. It is well known that changes to the ECM inhibit axonal regeneration it is also becoming clear that such alterations, particularly chondroitin sulphate proteoglycans (CSPGs) accumulation, impair oligodendrocyte function and remyelination. In order to enhance therapeutic efficacy, many studies have reported benefits from remodeling the extracellular matrix to provide a suitable scaffold for regeneration of cells and axons. Therefore, due to the effects of various ECM components on signaling events, it is very difficult to design controlled experiments for ECM-based cell signaling. It is also difficult to gelatinize nano or picogram quantities of collagen or the other single ECM component alone. Meanwhile, our ability to maintain stable cell density throughout experiments is limited when using several cell lines that do not have consistent adherence to culture flasks. ECM can be focused in basic investigations for understanding its roles and making engineered scaffolds mimicking ECM to treat SCI.
کلیدواژه‌های انگلیسی مقاله Traumatic Brain Injury, ECM, Cell Signaling
نویسندگان مقاله شاهین محمد صادقی | shahin mohammad sadeghi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. department of plastic and reconstructive surgery, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

سجاد سحاب نگاه | sajad sahab negah
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی کاظمی | hadi kazemi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. pediatric department, shahed university, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی علیقلی | hadi aligholi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

مصطفی مدرس موسوی | mostafa modarres mousavi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

ذبیح اله خاکسار | zabihollah khaksar
histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه شیراز (Shiraz university)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-446&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332296.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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