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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۸۹-۸۹
عنوان فارسی P۳۹: Effect of Injured Brain Extract on Proliferation of Neural Stem/Progenitor Cells Cultured in a ۳-dimensional Scaffold
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P39: Effect of Injured Brain Extract on Proliferation of Neural Stem/Progenitor Cells Cultured in a 3-dimensional Scaffold
چکیده انگلیسی مقاله Neuroinflamation occurring after traumatic brain injury (TBI) is a complex phenomenon comprising distinct cellular and molecular events involving the injured cerebral tissue. Mechanical injury to adult rat brain elucidated the accumulation in the affected area of trophic activity. In the tissue adjacent to the injury, trophic titers began to rise after the lesion. This study aimed to determine the effect of injured brain extract on proliferation of neonatal rat neural stem/progenitor cells (NS/PCs). NS/PCs were isolated from olfactory bulb of neonatal rat then cultured as neurospheres. After second passage, cells were seeded in PuraMatrix scaffold by injection method and incubated with intact or injured brain extracts. The proliferation assay was carried out by MTS assay 10 days later. For preparation of the injured brain extract, we used a rat brain injury model and collected the extract 48 hrs after injury. The experimental results showed that NS/PCs derived olfactory bulb have a good potential to proliferate. MTS assay demonstrated that NP/SCs proliferation rate was increased in injured brain extract. Injured brain extract could be benefit for NP/SCs proliferation.
کلیدواژه‌های انگلیسی مقاله Brain Extract, Proliferation, Scaffold
نویسندگان مقاله سجاد سحاب نگاه | sajad sahab negah
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran. b. histology and embryology group, basic science department, veterinary medicine faculty, shiraz university, shiraz, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

هادی علیقلی | hadi aligholi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

شاهین محمد صادقی | shahin mohammad sadeghi
department of plastic and reconstructive surgery, shahid beheshti university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

مصطفی مدرس موسوی | mostafa modarres mousavi
shefa neuroscience research center, khatam alanbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-435&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332286.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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