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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۸۵-۸۵
عنوان فارسی P۳۵: Neuroprotective Effect of Noscapine on Cerebral Oxygen-Glucose Deprivation Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P35: Neuroprotective Effect of Noscapine on Cerebral Oxygen-Glucose Deprivation Injury
چکیده انگلیسی مقاله The present study aims to investigate the effect of noscapine (0.5-2.5 µM), an alkaloid from the opium poppy, on primary murine fetal cortical neurons exposed to oxygen–glucose deprivation (OGD), an in vitro model of ischemia. Cells were transferred to glucose-free DMEM (Dulbecco's Modified Eagle Medium) and were exposed to hypoxia in a small anaerobic chamber. Cell viability and nitric oxide production were evaluated by MTT assay and the Griess method, respectively. 0.5 µM noscapine were significantly inhibited the neurotoxicities produced by 30 min OGD. The neurotoxicity decreased by noscapine treatment in the concentration-dependent manner. Pretreatment of cells with MK-801(10 µM), a non-competitive NMDA (N-Methyl-D-aspartate) antagonist, and nimodipine (10 nM), a L-type Ca2+ channel blockers, increased cell viability after 30 min OGD, while the application of NBQX (30 µM), a selective AMPA(-α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid)-kainate receptor antagonist partially attenuated cell injury. Noscapine attenuated nitric oxide (NO) production in cortical neurons after 30 min OGD. We concluded that noscapine had a neuroprotective effect, which could be due to its interference with multiple targets in the excitotoxicity process. These effects could be mediated partially by a decrease in NO production.
کلیدواژه‌های انگلیسی مقاله Noscapine, NO, Oxygen-Glucose Deprivation, Cortical Culture
نویسندگان مقاله گلاره وهاب زاده | gelareh vahabzadeh
cellular and molecular research center, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

سلطان احمد ابراهیمی | soltan ahmad ebrahimi
department of pharmacology, faculty of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

ناهید رهبر روشندل | nahid rahbar roshandel
department of pharmacology, faculty of medicine, iran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی ایران (Iran university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-431&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332282.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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