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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۶۱-۶۱
عنوان فارسی P۱۱: Evening Primrose Oil Improves Nerve Functions Following Crush Injury of Sciatic Nerve in Rats
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عنوان انگلیسی P11: Evening Primrose Oil Improves Nerve Functions Following Crush Injury of Sciatic Nerve in Rats
چکیده انگلیسی مقاله Repairing the damaged nerves caused by physical injury (trauma), is one of the major challenges facing modern medical sciences. Evening primrose oil (EPO) extraction of Oenothera Biennis seed that enriches with omega-6,γ-linoleic acid and linoleic acid that they have essential role in myelination and neural membrane structure. The aim of this study was to evaluate the functional recovery of sciatic nerve after EPO administration in crushed sciatic nerves. Eighteen male Wistar rats with 180 - 200g weight divided in 3 groups: sham, saline, EPO. In 12 anesthetized rats in saline, EPO groups, the right sciatic nerve was crushed using a small hemostatic forceps. EPO, 450 mg/kg/day, was orally administrated for 28 days. Gastrocnemius muscle atrophy was investigated using light microscopy. Functional recovery of the nerves was assessed using sciatic functional index SFI one day before injury and 7, 14, 21 and 28days after injury. The result of this study showed that in EPO group, functional recovery of sciatic nerve significantly accelerated compared with group 2 that received saline. In addition the muscular atrophy improvement was greater in EPO group compared with saline group. The present study showed that EPO induced improving effect on motor function and muscular atrophy caused by nerve crush injury.
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نویسندگان مقاله امید بدری | omid badri
department of physiology, school of medicine, tabriz university of medical sceinces, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

پرویز شهابی | parviz shahabi
neuroscience research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

مهدی فرهودی | mehdi farhoudi
neuroscience research center, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

محسن شریف زاک | mohsen sharif zak
department of biochemistry, school of medicine, tabriz university of medical sceinces, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه تبریز (Tabriz university)

آرمین آزادی | armin azadi
department of management of informatics. school of management, tabriz university of medical sciences, tabriz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تبریز (Tabriz university of medical sciences)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-407&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332258.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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