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مجله علوم اعصاب شفای خاتم، جلد ۲، شماره ۴، صفحات ۳۶-۳۶
عنوان فارسی O۳۶: Three-Dimensional Transplantation of Adult Neural Stem Cells in an Acute Brain Injury Model
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی O36: Three-Dimensional Transplantation of Adult Neural Stem Cells in an Acute Brain Injury Model
چکیده انگلیسی مقاله Brain injury is the leading cause of death and disability in the most active population. There is no definite clinical treatment for repair of damaged brain tissue. Application of nanoscaffolds supporting stem cells can be helpful. The present study examined the effects of autologous adult neural stem/progenitor cells (NS/PCs) seeded in PuraMatrix in acute brain injury. The right brain subventricular zone of adult wistar rats was stereotactically harvested. Then, NS/PCs were cultured using neurosphere assay. At day 45, brain injury was performed in left side of brain and PBS, PuraMatrix, NS/PCs or PuraMatrix+ NS/PCs was injected into the created cavity. The neurological status was evaluated for 4 weeks. Then, morphological and immunohistochemical studies were done. The neurologic status improved after treatment of brain injury with PuraMatrix, NS/PCs or PuraMatrix + NS/PCs. The lesion volume was decreased in PuraMatrix+ NS/PCs. By 3D transplantation of NS/PCs, not only the rate of inflammation was reduced but also the survival rate in the site of injury was increased. In addition, the transplanted cells expressed the differentiation markers after 4 weeks. Transplantation of adult NS/PCs in PuraMatrix may be a feasible method for reduction of tissue damage following brain injury.
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نویسندگان مقاله هادی علیقلی | hadi aligholi
a. shefa neuroscience research center, khatam- al- anbia hospital, tehran, iran. b. department of neuroscience, school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

غلامرضا حسن زاده | gholamreza hassanzadeh
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مهدی رضایت | mahdi rezayat
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

حسن آذری | hassan azari
a. neural stem cell amp;amp; regenerative neuroscience laboratory, department of anatomical sciences, school of medicine, shiraz, iran. b. shiraz stem cell institute, shiraz university of medical sciences, shiraz, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شیراز (Shiraz university of medical sciences)

شهرام اجتماعی مهر | shahram ejtemaei mehr
department of pharmacology, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

محمد اکبری | mohammad akbari
department of anatomy, school of medicine, tehran university of medical sciences, tehran, iran.

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

مصطفی مدرس موسوی | mostafa modarres mousavi
shefa neuroscience research center, khatam- al- anbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

فاطمه علیپور | fatemeh alipour
shefa neuroscience research center, khatam- al- anbia hospital, tehran, iran.

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

علی گرجی | ali gorji
a. epilepsy research center and b. department of neurosurgery and neurology, westfälische wilhelms-universität münster, robert-koch-strasse 27a, 48149 münster, germany.
نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-381&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332233.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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