این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
مجله علوم اعصاب شفای خاتم، جلد ۳، شماره ۴، صفحات ۳۴-۳۴
عنوان فارسی P۷: Valproic Acid Mediated Neuroprotection and Neurogenesis after Acute Spinal Cord Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی P7: Valproic Acid Mediated Neuroprotection and Neurogenesis after Acute Spinal Cord Injury
چکیده انگلیسی مقاله Spinal cord injury (SCI)-induced systemic inflammatory response affects multiple organs outside the spi­nal cord. Treatment options for such complications are lacking. Valproic acid (VPA) is a histone deacetylase inhibitor, acting directly at the level of gene transcription by inhibiting histone deacetylation and making transcription sites more accessible. Acetylation of histones is critical to cellular inflammatory and repair processes. A recent study demonstrated that VPA has effects on neuroprotection and neurogenesis for the treatment of the injured spinal cord. VPA can decreases glial apoptosis, neruoinflammation, neurotoxicity and autophagy during the secondary injury period, and upregulates prosurvival neurotrophic factors. The neuroprotective effects of VPA are interdepend and mediated by HDAC inhibition and GSK-3 inhibition. VPA increased several stages of neurogenesis, including the proliferation of endogenous neural stem cells, neuronal differentiation and maturation, neurite outgrowth, and synaptic integration. In addition, VPA can promote neurogenesis even after spinal cord cells are damaged, by controling the expression of important transcriptional factors and the activation of multiple signaling pathways. Furthermore, the effects and mechanisms of VPA on neuronal excitation mediated neuroprotection and neurogenesis are cooperated and interconnected in treating SCI. It is necessary to optimize VPA treatment processes for SCI on aspects of therapeutic timing, effective dosage, and reliable administration route. Combinatory strategies should be established to maximize the benefits of VPA and to reduce adverse events. Specific criteria must be met prior to translating VPA treatment for SCI from animal experiments to clinical trials.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله سارا عبدالهی | sara abdolahi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of biotechnology, school of veterinary science, shiraz university, shiraz, iran

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

مریم برهانی حقیقی | maryam borhani haghighi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of anatomy, tehran university of medical science, tehran, iran

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

حسن حسینی روندی | hassan hosseini ravandi
a.shefa neuroscience research center, khatam alanbia hospital, tehran, iran

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-640&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332120.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات