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مجله علوم اعصاب شفای خاتم، جلد ۴، شماره ۴، صفحات ۲۹-۲۹
عنوان فارسی P۷: Current Status of Fibrin-Based Scaffolds in the Treatment of Spinal Cord Injury
چکیده فارسی مقاله لطفاً به چکیده انگلیسی مراجعه شود.
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عنوان انگلیسی P7: Current Status of Fibrin-Based Scaffolds in the Treatment of Spinal Cord Injury
چکیده انگلیسی مقاله Spinal cord injury (SCI) results in the damage of motor and sensory pathways. The molecular and cellular structure of the injury milieu has been shown to be vital for endogenous regeneration in most tissues. Regeneration of Injured central nervous system (CNS) is limited by damaged cell environment. Biomaterial scaffolds can reconstruct injured CNS tissue following SCI by promoting the migration of support cells into the biomaterial and enhancing axonal regeneration. Fibrin gel self-assembles into a scaffold by simulating the last stage of blood clotting to support cell migration, proliferation, differentiation, and eventually tissue regeneration. Fibrin is a suitable biomaterial scaffold for nerve regeneration based on its role in wound repair and tissue renovation. Fibrin Gel also been investigated as an Injectable biodegradable scaffold and cell carrier for healing of spinal cord injury. Fibrin has been used as a matrix to seal nerve guidance tubes implanted following sciatic nerve injury in neural tissue engineering and was shown to promote axonal renewal and cell migration. Fibrin scaffolds have also been used in acute studies of whole spinal cord transection, and were found to elicit improved neural fiber sprouting at early time points. Fibrin scaffolds can be amended covalently to form an affinity-based delivery system for the regulated delivery of neurotrophins. Future work will study the effect of fibrin scaffolds in combination with other treatment techniques such as protein delivery on spinal cord regeneration following injury.
کلیدواژه‌های انگلیسی مقاله Nerve, Scaffold, Spinal cord, Regeneration
نویسندگان مقاله مریم برهانی حقیقی | maryam borhani haghighi
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. department of anatomy, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه علیپور | fatemeh alipour
shefa neuroscience research center, khatam alanbia hospital, tehran, iran

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-798&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332008.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده مروری
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