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مجله علوم اعصاب شفای خاتم، جلد ۴، شماره ۴، صفحات ۲۵-۲۵
عنوان فارسی P۳: Neuronal Death Following Posttraumatic Excitability and Seizure
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عنوان انگلیسی P3: Neuronal Death Following Posttraumatic Excitability and Seizure
چکیده انگلیسی مقاله Seizure may occur after mild traumatic brain injury (TBI), and the severity of TBI can be considered the most crucial factor for an increased risk of recurring seizures as well as for the development of posttraumatic epilepsy. However, the effect of seizures in epileptogenesis after mild TBI cannot yet be accurately confirmed. This study was designed to determine whether mild TBI increases seizure susceptibility as well as to investigate the histopathological and molecular consequences of seizure occurrence after mild TBI. Using a novel method of TBI induction, seizures were induced by sub-convulsive doses of pentylenetetrazole (PTZ) fifteen days after induction of focal mild TBI. Behavioral assessments were performed for one hour after PTZ injection and histopathological as well as molecular evaluations were performed. A significantly higher score and longer duration of seizure attacks were observed in the TBI+PTZ group compared to sham and TBI groups. A higher number of apoptotic cells was observed in the TBI+PTZ group compared to sham and TBI rats. Molecular investigations revealed higher levels of Bax/Bcl2 ratio, Caspase 3, and NF-κB in the TBI+PTZ group compared to the other animal groups. Our data indicated that seizure occurrence following mild TBI aggravates cell injury and death via activation of neuroinflammatory processes and may increase the risk of posttraumatic epilepsy. 
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نویسندگان مقاله طاهره قدیری | tahereh ghadiri
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فریبا خداقلی | fariba khodagholi
neuroscience research center, shahid beheshti university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی شهید بهشتی (Shahid beheshti university of medical sciences)

گلاره وکیل زاده | gelareh vakilzadeh
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

وحید حاج علی | vahid hajali
quchan higher health education center, mashhad university of medical sciences, mashhad, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی مشهد (Mashhad university of medical sciences)

محمد شریف زاده | mohammad sharifzadeh
a. department of toxicology, faculty of pharmacy, tehran university of medical sciences, tehran, iran b. school of advanced technologies in medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

علی گرجی | ali gorji
a. shefa neuroscience research center, khatam alanbia hospital, tehran, iran b. razavi neuroscience center, razavi hospital, mashhad, iran c. department of neurosurgery, department of neurology and epilepsy research center, munster university, germany

سازمان اصلی تایید شده: مرکز تحقیقات علوم اعصاب شفا (Shefa neuroscience research center)

نشانی اینترنتی http://shefayekhatam.ir/browse.php?a_code=A-10-24-794&slc_lang=fa&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/337/article-337-332004.pdf
کد مقاله (doi)
زبان مقاله منتشر شده fa
موضوعات مقاله منتشر شده تحقیقات پایه در علوم اعصاب
نوع مقاله منتشر شده پژوهشی
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