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World Journal of Plastic Surgery، جلد ۶، شماره ۱، صفحات ۵۴-۶۱
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effect of Systemic Antioxidant Allopurinol Therapy on Skin Flap Survival
چکیده انگلیسی مقاله BACKGROUND It has been reported that systemic administration of allopurinol improves cell survival. This study was aimed to evaluate effects of allopurinol on skin flaps in dogs. METHODS Twenty dogs underwent one skin flap surgery with a 2-week interval. The first procedure was performed according to the standard protocols. The second phase was started by a 1-week pretreatment with allopurinol. Length of the necrotic zone was measured and recorded daily. At each phase, flaps were removed and sent for histopathological study after 1 week observation. RESULTS Mean length of the necrotic zone in allopurinol treated skin flaps has been significantly less than normal flaps over all 7 days of observation (p< 0.0001). Histopathology study showed less inflammation and more normal tissue structure in the allopurinol treated skin flaps. CONCLUSION It was demonstrated that systemic administration of allopurinol significantly improved skin flap survival.
کلیدواژه‌های انگلیسی مقاله Allopurinol, Antioxidant, Skin flap, Survival
نویسندگان مقاله مهدی راستی اردکانی | mehdi rasti ardakani
department of plastic surgery, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

احمد al dam | ahmed al dam
department of oral and maxillofacial surgery, university medical center hamburg-eppendorf, hamburg, germany.


اشکان رشاد | ashkan rashad
department of oral and maxillofacial surgery, university medical center hamburg-eppendorf, hamburg, germany.


علی شایسته مقدم | ali shayesteh moghadam
240 east, 55th street,new york,ny,10022
نشانی اینترنتی http://wjps.ir/browse.php?a_code=A-10-185-1&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/239/article-239-331252.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده عمومی
نوع مقاله منتشر شده مقالات اصیل
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