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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۰۳، صفحات ۰-۰
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Effects of melatonin on left ventricular ejection fraction and functional class of heart failure patients: A randomized, double-blind, placebo-controlled trial
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-fareast-font-family:"Times New Roman"; mso-fareast-theme-font:minor-fareast; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} BACKGROUND : Melatonin, a hormone secreted by the pineal gland, has multiple effects on circadian physiology, blood pressure, and coronary blood flow. It has also free radical scavenger and anti-oxidative activity. This study was planned to evaluate the effects of melatonin on left ventricular function of patients with heart failure. METHODS : In this randomized double-blind clinical trial, 60 patients with heart failure (based on clinical and echocardiography findings) admitted to Shahid Chamran and Khorshid Hospitals in Isfahan, Iran in 2010 received 3 mg melatonin or placebo for 2 months. New York Heart Association (NYHA) functional class and left ventricular ejection fraction (LVEF) in each group, before and after the study were compared. Comparisons were also made between the two groups each step. The data was analyzed by appropriate statistical methods. RESULTS : Overall, 60 patients (41 males and 19 females) participated in this study. LVEF increased from 31.7 to 37.6 in the case group (p < 0.001) and from 34.1 to 35.2 in the control group (p = 0.42). NYHA functional class improved only in the case group (p = 0.014 versus 0.317). CONCLUSIONS : This study revealed that melatonin may have beneficial effects on patients with heart failure. However, larger studies may help to define its role in heart failure management. KEYWORDS : Melatonin; Heart Failure; New York Heart Association; Left Ventricular Ejection Fraction.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله محمد گرک یراقی | mohammad garakyaraghi
associate professor of cardiology, isfahan university of medical sciences, isfahan cardiovascular research center, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

منصور سیاوش | mansour siavash
associate professor of endocrinology, isfahan university of medical sciences, isfahan endocrine and metabolism research center, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

محمد کاظم علیزاده | mohammad kazem alizadeh
resident of cardiology, school of medicine and student research committee, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8198
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-331002.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Articles
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