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Journal of Research in Medical Sciences، جلد ۱۷، شماره ۰۳، صفحات ۰-۰
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عنوان انگلیسی Efficacy and safety of morphine versus methadone for patient-controlled analgesia: a randomized clinical trial
چکیده انگلیسی مقاله Normal 0 false false false EN-US X-NONE AR-SA MicrosoftInternetExplorer4 /* Style Definitions */ table.MsoNormalTable {mso-style-name:"Table Normal"; mso-tstyle-rowband-size:0; mso-tstyle-colband-size:0; mso-style-noshow:yes; mso-style-priority:99; mso-style-qformat:yes; mso-style-parent:""; mso-padding-alt:0in 5.4pt 0in 5.4pt; mso-para-margin-top:0in; mso-para-margin-right:0in; mso-para-margin-bottom:10.0pt; mso-para-margin-left:0in; line-height:115%; mso-pagination:widow-orphan; font-size:11.0pt; font-family:"Calibri","sans-serif"; mso-ascii-font-family:Calibri; mso-ascii-theme-font:minor-latin; mso-hansi-font-family:Calibri; mso-hansi-theme-font:minor-latin; mso-bidi-font-family:Arial; mso-bidi-theme-font:minor-bidi;} BACKGROUND : The aim of the study was to evaluate the efficacy and safety of intravenous patient-controlled analgesia (PCA) morphine versus intravenous PCA with methadone for postoperative pain management. METHODS : In a randomized controlled clinical trial, 400 patients were randomly allocated to receive either morphine or methadone delivered via intravenous PCA after surgery. Patients were followed for 24 hours after surgery. Pain and patient satisfaction was assessed via numeric rating scale as well as sedation score. Data on the incidence of nausea and vomiting, severe sedation and pruritus were also collected. RESULTS : Pain scores at 1 and 3 hours postoperatively in the morphine group was significantly higher than methadone group (p < 0.05), but the trend of pain score, sedation score and the incidence of nausea and vomiting during the 24 hours follow-up were not significantly different between groups. Patients in the methadone group had higher ratings of satisfaction than the morphine group (p = 0.001). Incidence of pruritus in morphine group were higher than the methadone group (P-value = 0.006). CONCLUSIONS : PCA with methadone might be more effective than PCA with morphine in reducing postoperative pain during the first hours after surgery with less frequency of pruritus. KEYWORDS : Patient-controlled Analgesia, Morphine, Methadone, Pain Management
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نویسندگان مقاله امین ابن شهیدی | amin ebneshahidi
anesthesiologist, sadi hospital, isfahan, iran


مجتبی اکبری | mojtaba akbari
epidemiologist, isfahan university of medical sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی اصفهان (Isfahan university of medical sciences)

مسعود محسنی | masood mohseni
assistant professor, department of anesthesiology, school of medicine, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهرام حشمتی | bahram heshmati
public health, persia research center, isfahan, iran


امید آقاداودی | omid aghadavoudi
associate professor, department of anesthesiology and critical care, school of medicine, isfahan university of medi-cal sciences, isfahan, iran

سازمان اصلی تایید شده: دانشگاه اصفهان (Isfahan university)

نشانی اینترنتی http://jrms.mui.ac.ir/index.php/jrms/article/view/8150
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/218/article-218-331001.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Articles
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