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Iranian Journal of Diabetes and Obesity، جلد ۸، شماره ۲، صفحات ۷۷-۸۴
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عنوان انگلیسی Anti-Inflammatory Effects of Atorvastatin by the Modulation of NF-κB Expression during Hyperglycemia-Induced Nephropathy in Rat
چکیده انگلیسی مقاله Objective: Atorvastatin has the pleiotropic effects, including anti-inflammation and antioxidant. Therefore, this study considered to examine the effects of atorvastatin on NF-қB expression, as a main transcription factor for expression of inflammatory cytokines, in hyperglycemia-induced nephropathy in rat. Materials and Methods: Twenty four male Wistar rats were randomly divided into four groups; Normal, Normal treatment, Diabetic, and Diabetic treatment. Rats were made diabetic by an intravenous injection of streptozotocin (40 mg/kg). Treated rats received atorvastatin for 60 days (40 mg/kg/day). At the end of experiment, blood samples were collected for measurement of blood glucose. Moreover, the mRNA expression level of NF-қB in kidney was determined by RT-PCR technique. Results: Induction of diabetes significantly increased the mean value of blood glucose in diabetic rats (>450 mg/dl) compared with normal rats (P=0.001). Chronic hyperglycemia also increased the mRNA expression level of NF-қB in diabetic kidney. Moreover, the mean value of kidney index was significantly increased in diabetic rats compared to normal group (P=0.001). Treatment with atorvastatin in diabetic rats for 60 days reduced the mRNA expression level of NF-қB and kidney index compared to non-treated diabetic rats (P=0.014). Conclusion: Our findings revealed that atorvastatin is able to prevent the development of diabetic nephropathy during chronic uncontrolled hyperglycemia possibly by the inhibition of NF-қB expression in the kidneys of diabetic rats.
کلیدواژه‌های انگلیسی مقاله Nephropathy, Atorvastatin, Hyperglycemia, NF-қB
نویسندگان مقاله محمد تقی محمدی | mohammad taghi mohammadi
. department of physiology and biophysics, faculty of medicine, baqiyatallah university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی بقیه الله (Baqiyatallah university of medical sciences)

نسترن فقیهی | nastaran faghihi
department of biology, science and research branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

اکرم عیدی | akram eidi
department of biology, science and research branch, islamic azad university, tehran, iran

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://ijdo.ssu.ac.ir/browse.php?a_code=A-10-30-141&slc_lang=en&sid=en
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/213/article-213-330934.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده پژوهشی
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