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فصلنامه علمی پژوهشی گیاهان دارویی، جلد ۱، شماره ۳۳، صفحات ۱۰۷-۱۱۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Compartments of Quercetin & Allium cepa (Onion) on Blood Glucose in Diabetic Rats
چکیده انگلیسی مقاله Background : The major concern in diabetes is increased oxidative stress. Maintaining a balance between reactive oxygen species (ROS) and antioxidants is a major mechanism in preventing damage from oxidative stress. Quercetin (QR) is a well-known flavonoid and a strong antioxidant derived from the onion, Allium cepa, and it has been shown to reduce oxidative stress in the long-term treatment of streptozotocin (STZ)-induced diabetes in animals. Objective: We aimed to study on beneficial effects of QR & Allium cepa on regulation of blood glucose in diabetic model. Methods : Seventy male 8-week-old Wistar albino rats weighing 250 ± 10 g were obtained, the rats were divided into seven groups comprising ten animals in each group. Diabetes induced with single intraperitoneal injection of STZ. Diabetic rats treated with quercetin (15mg/kg/day, started 48 hours after STZ injection) and Allium cepa juice (2cc/rat/day, started 48 hours after STZ injection). After 28 days treatment, analysis on blood glucose and insulin was done. Results : The mean TAC showed a significant increase (p < 0.05) in the QR compared to the control, STZ and STZ + QR groups. Both QR and onion Juice had significant effect in lowering blood glucose (355.3 ± 104 mg/dl and 353.4 ± 103 mg/dl respectively) (p< 0.05) in STZ induced diabetic animals. Both QR and onion juice had lowering effect in Serum insulin in healthy animals and significant increasing effect on serum insulin level in diabetic animals. Conclusions : Both QR and onion juice had good effect in modifying diabetes related biochemical parameters and they are recommended to be studied more in order to being used in the therapy.
کلیدواژه‌های انگلیسی مقاله Quercetin, Onion, Diabetes, Rat
نویسندگان مقاله a خاکی | a khaki
department of veterinary pathology, islamic azad university, tabriz branch, iran, 1 etekali la, south shariati street, tabriz, iran, mobile phone 98-9143138-399

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

f فتحی آزاد | f fathiazad
department of pharmacognosy tabriz medical university, tabriz


hr احمدی آشتیانی | hr ahmadi ashtiani
department of clinical biochemistry, school of medical science, tarbiat-e-modarres university, tehran, iran amp;amp; biochemistry and nutrition department of zanjan university of medical sciences, zanjan, institute of medicinal plants, acecr, tehran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی زنجان (Zanjan university of medical sciences)

sh رضازاده | sh rezazadeh
institute of medicinal plants, acecr, tehran

سازمان اصلی تایید شده: پژوهشکده‮ ‬گیاهان‮ ‬دارویی‮ ‬جهاد‮ ‬دانشگاهی (Institute of medicinal plants)

h رستگار | h rastegar
ministry of health and medical education, food amp;amp; drug laboratory research center, tehran

سازمان اصلی تایید شده: وزارت بهداشت درمان و آموزش پزشکی (Ministry of health and medical education)

am ایمانی | am imani
department of veterinary pathology, islamic azad university, tabriz branch, tabriz

سازمان اصلی تایید شده: دانشگاه آزاد اسلامی علوم و تحقیقات (Islamic azad university science and research branch)

نشانی اینترنتی http://jmp.ir/browse.php?a_code=A-10-176-9&slc_lang=en&sid=fa
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/88/article-88-329655.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده دامپزشکی
نوع مقاله منتشر شده پژوهشی
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