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Iranian Biomedical Journal، جلد ۲۸، شماره ۱، صفحات ۸-۱۴
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Celiac Disease: A Review from Genetic to Treatment
چکیده انگلیسی مقاله
Celiac disease (CD) is a complex disorder influenced by genetic and environmental factors. When people with a genetic predisposition to CD consume gluten, an inflammatory response is triggered in the small intestine, and this reaction can be alleviated by the elimination of gluten from the diet. The clinical manifestations of CD vary greatly from person to person and begin at a young age or in adulthood. Influence of genetic factors on CD development is evident in carriers of the DQ2 and/or DQ8 allele. HLA genotypes are associated with gut colonization by bacteria, particularly in individuals suffering from CD. In addition, beneficial gut microbes are crucial for the production of DPP-4, which plays a key role in immune function, as well as metabolic and intestinal health. Therefore, probiotics have been recommended as a complementary food supplement in CD.
کلیدواژه‌های انگلیسی مقاله Celiac disease, Dipeptidyl peptidase 4, HLA-DQ antigens, Probiotics
نویسندگان مقاله | Erfaneh Jafari
Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Niloufar Soleymani
Department of Food Hygiene, Islamic Azad University (Science and Research Branch), Tehran, Iran


| Masoud Hamidi
École Polytechnique de Bruxelles-BioMatter Unit, Université Libre de Bruxelles (ULB), Brussels, Belgium


| Azar Rahi
Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran


| Akram Rezaei
Department of Microbiology, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran


| Reza Azizian*
Pediatric Infectious Disease Research Center, Tehran University of Medical Sciences, Tehran, Iran
نشانی اینترنتی http://ibj.pasteur.ac.ir/browse.php?a_code=A-10-5568-1&slc_lang=en&sid=1
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کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده Related Fields
نوع مقاله منتشر شده مینی ریویو
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