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Iranian Journal of Kidney Diseases، جلد ۱۱، شماره ۲، صفحات ۱۲۴-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Protective Effect of Quercetin Against Oxidative Stress-induced Toxicity Associated With Doxorubicin and Cyclophosphamide in Rat Kidney and Liver Tissue |
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| چکیده انگلیسی مقاله |
Introduction. Doxorubicin and cyclophosphamide are widely used anticancer drugs with substantial toxicity in noncancerous tissue resulting from oxidative damage. Quercetin is a potent antioxidant compound. We hypothesized that quercetin administration would ameliorate the toxic effects of doxorubicin and cyclophosphamide prior to pregnancy. Materials and Methods. Cyclophosphamide, 27 mg/kg, and doxorubicin, 1.8 mg/kg, were administered to rats as intraperitoneal doses once every 3 weeks for a total of 10 weeks with or without concurrent treatment with quercetin, 10 mg/kg/d. Oxidative stress parameters were evaluated in maternal kidney and liver tissues after gestation. Results. Doxorubicin was associated with elevated kidney tissue malondialdehyde relative to the controls and quercetin only treatment ( P < .05). Both cyclophosphamide and doxorubicin were associated with elevated malondialdehyde levels in the liver tissue ( P < .05). Doxorubicin treatment was associated with decreased liver glutathione peroxidase ( P < .05). Quercetin treatment suppressed the accumulation of malondialdehyde and increased glutathione peroxidase levels during doxorubicin and cyclophosphamide treatment ( P |
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| کلیدواژه‌های انگلیسی مقاله |
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| نویسندگان مقاله |
صیاد kocahan | sayad kocahan
zumrut دوغان | zumrut dogan
erman erdemli | erman erdemli
eylem تسکین | eylem taskin
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| نشانی اینترنتی |
http://www.ijkd.org/index.php/ijkd/article/view/2860 |
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| زبان مقاله منتشر شده |
en |
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