این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
Iranian Journal of Public Health، جلد ۵۳، شماره ۱۰، صفحات ۲۳۰۷-۲۳۱۷
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Causal Relationships between Circulating Immune Cell Traits and the Risk of Rheumatoid Arthritis and Osteoarthritis: A Bidirectional Two-Sample Mendelian Randomization Study
چکیده انگلیسی مقاله Background: Rheumatoid arthritis (RA) and osteoarthritis (OA) are prevalent chronic joint disorders with immunological pathogenesis. However, the causal relationships between circulating immune cells and them remain largely unknown. Therefore, we conducted a bidirectional two-sample Mendelian randomization (MR) study to determine their causal relationship. Methods: Genome-wide association study summary statistics were extracted from publicly available databases regarding immune cell phenotypes, RA, and OA. MR analysis was conducted using five MR methods, with inverse-variance-weighted (IVW) as the primary analysis method. False discovery rate correction (FDR) was used to reduce the likelihood of type 1 errors. We also conducted MR-Egger intercept tests to evaluate horizontal pleiotropy. Results: After FDR adjustment of the P values for the IVW method, the CD27 expression on memory B cells was negatively related to the risk of RA (P < 0.001), and the human leukocyte antigen (HLA)--DR expression on CD14+ monocytes was negatively related to the risk of OA (P < 0.001). We also found that RA was negatively associated with the expression of HLA-DR on myeloid dendritic cells (P < 0.001), but significant horizontal pleiotropy was observed. Conclusion: Our study demonstrates a causal relationship between specific immune cell traits and RA as well as OA, providing further insight into the role of immune cells in the pathogenesis of these disorders.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Dujuan Mao
Department of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China


| Shan Li
Department of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China


| Xiufang Li
Department of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China


| Lijuan You
Department of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China


| Jiaqi Yu
Department of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China


| Yaohua Wu
Department of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China


| Quanshui Hao
Department of Anesthesiology, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang 438000, Hubei, China


| Heng Du
Department of Gastrointestinal Surgery, Huanggang Central Hospital Affiliated to Yangtze University, Huanggang, 438000, Hubei, China
نشانی اینترنتی https://ijph.tums.ac.ir/index.php/ijph/article/view/34985
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات