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Avicenna Journal of Phytomedicine، جلد ۱۴، شماره ۵، صفحات ۵۶۱-۵۶۹
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی The effect of evening primrose oil on adolescent girl patients with PCOS: A double-blind placebo-controlled randomized study
چکیده انگلیسی مقاله Objective: Polycystic ovary syndrome (PCOS) is a common disorder among women of reproductive age. The goal of the current study was to evaluate the effect of evening primrose oil (EPO) (Oenothera biennis) in adolescent girls with PCOS.Materials and Methods: In the current double-blind and randomized controlled research, 76 patients completed the study in two groups (38 in the placebo and 38 in the EPO groups). The patients were asked to take oral placebo or EPO (1000 mg/day) for 12 weeks. Biochemical, clinical, and ultrasonography assessments were performed. The data was analyzed using SPSS statistical software.Results: After the intervention, the regulation of the menstrual cycle in the EPO group was different from that of the placebo group (p=0.04). The levels of insulin, testosterone, and free androgen index (FAI) in the EPO group were lower than those of the placebo group (p<0.05). The sex hormone binding globulin (SHBG) levels in the EPO group were higher than those of the placebo group (p=0.01). While the number of immature follicles decreased in the EPO group, this difference was not statistically significant (p=0.8).Conclusion: Overall, EPO administration for 12 weeks in young women with PCOS regulated the irregular menstrual cycle. In addition, the levels of insulin, testosterone, FAI, and SHBG changed. Therefore, EPO may be effective in improving hormonal and menstrual irregularities.
کلیدواژه‌های انگلیسی مقاله Evening Primrose Oil, PCOS, Insulin, Testosterone, FAI, SHBG
نویسندگان مقاله | Laila Mohammadlo
Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Kaveh Rahimi
Department of Basic Sciences, Faculty of Veterinary Medicine, Shahid Chamran University of Ahvaz, Ahvaz, Iran


| Masomeh Rezaie
Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Nasrin Soufizadeh
Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Fariba Seyedoshohadaei
Department of Obstetrics and Gynecology, Faculty of Medicine, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Khaled Rahmani
Liver and Digestive Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Sanandaj, Iran


| Reza Bekhradi
Barij Medicinal Plants Research Center, Kashan, Iran
نشانی اینترنتی https://ajp.mums.ac.ir/article_24342.html
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Research Article
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