|
|
Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۳، شماره ۴، صفحات ۱۴۷۰-۱۴۸۱
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Selective Simple Solid Phase Extraction Coupled with High-Performance Liquid Chromatography Determination of Repaglinide by Functionalized SBA-15 Nanoadsorbent |
|
| چکیده انگلیسی مقاله |
The straightforward Solid-Phase Extraction (SPE) approach coupled with High-Performance Liquid Chromatography (HPLC) was studied for its potential use in the measurement of low-concentration levels of Repaglinide (REP), a common anti-diabetic medicine. In this study, we successfully synthesized nanoparticles of phenyl-functionalized SBA-15 (referred to as SBA-15-Ph) and used them as an intelligent adsorbent to capture REP in certain biological samples. Some characterization and verification methods were used to outline the mesoporous silica nanoparticles; these methods included Fourier Transform InfraRed (FT-IR) spectroscopy, Small-Angle X-Ray Diffraction (SAXRD), Scanning Electron Microscopy (SEM), and N2 adsorption/desorption studies. The results showed that the phenyl functional groups were well absorbed into the surface of SBA-15 and that the as-made products exhibited hexagonal mesostructures. Significant merit values were also achieved, including a linear range spanning from 2.0 to 500 ng/mL, exhibiting a high correlation coefficient (R2) of 0.9947, and demonstrating a limit of detection as low as 0.68 ng/mL. Repaglinide samples were quickly cleaned up and enriched using the suggested approach for chromatographic analysis, demonstrating the method's efficacy. |
|
| کلیدواژه‌های انگلیسی مقاله |
nanoparticles,Plasma,Repaglinide,Solid phase extraction,Porous silica particles |
|
| نویسندگان مقاله |
Parinaz Pourahmadi |
Phase separation and FIA Lab., Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, I.R. IRAN
Naser Dalali |
Phase separation and FIA Lab., Department of Chemistry, Faculty of Science, University of Zanjan, Zanjan, I.R. IRAN
Mehrdad Hamidi |
Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, I.R. IRAN
Aziz Maleki |
Pharmaceutical Nanotechnology Research Center (ZPNRC), Zanjan University of Medical Sciences, Zanjan, I.R. IRAN
|
|
| نشانی اینترنتی |
https://ijcce.ac.ir/article_708607_7050a48d48cb06d74330bc027d659839.pdf |
| فایل مقاله |
فایلی برای مقاله ذخیره نشده است |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|