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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۳، شماره ۳، صفحات ۱۰۸۳-۱۰۹۳
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Synthesis, Enzyme Inhibition, and in Silico Studies of Amino Acid Schiff Bases |
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| چکیده انگلیسی مقاله |
In this research, novel complexes of Zn(II) were produced using amino acid Schiff bases. First, new Schiff bases were synthesized from the reaction of 3-methoxy-2-hydroxybenzaldehyde (o-vanillin) and amino acid methyl esters (isoleucine, phenylalanine, methionine). The synthesis of new complexes was carried out by the reaction of these Schiff bases and Zn(OAc)2.2H2O. The structures of the synthesized complexes were elucidated using elemental analysis, FT-IR, NMR, UV-vis spectroscopy, and thermal analysis techniques. In this research, we synthesized new complexes of Zn(II) with amino acid Schiff bases labeled as 1a-1c. We then examined their impact on specific metabolic enzymes, namely acetylcholinesterase (AChE) and butyrylcholinesterase (BChE). The results showed that the molecules exhibited potent inhibitory activities against all targets compared to the standard inhibitor as indicated by IC50 values. Ki values of the compounds for AChE and BChE enzymes were obtained in the range of 78.04±8.66-111.24±12.61 and 24.31±3.98-85.18±7.05 µM, respectively. Molecular docking calculations were performed to investigate the biological activities of the metal complexes. The Protein Ligand Interaction Profiler (PLIP) was used to study the chemical interactions of metal complexes with enzymes. |
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| کلیدواژه‌های انگلیسی مقاله |
Amino acid Schiff base,Zn(II) complexes,Bioactivity,docking,PLIP |
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| نویسندگان مقاله |
Nilay Akkuş Taş |
Chemistry Department, Art and Science Faculty, Amasya University, Amasya, TURKİYE
Ayşegül Şenocak |
Chemistry Department, Art and Science Faculty, Tokat Gaziosmanpasa University, Tokat, TURKİYE
Parham Taslimi |
Department of Biotechnology, Faculty of Science, Bartin University, Bartin, TURKİYE
Burak Tuzun |
Plant and Animal Production Department, Technical Sciences Vocational School of Sivas,
Sivas Cumhuriyet University, Sivas, TURKİYE
Ahmet Karadağ |
Department of Chemistry, Faculty of Arts and Sciences, Yozgat Bozok University, Yozgat, TURKEY
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| نشانی اینترنتی |
https://ijcce.ac.ir/article_708447_de43d2d129e3699c7b0ab7ef4424aece.pdf |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
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| نوع مقاله منتشر شده |
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