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Tanaffos، جلد ۲۲، شماره ۴، صفحات ۳۹۵-۴۰۲
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عنوان انگلیسی Oncologic Emergencies in Lung Cancer Patients and the Effects of SARS-COV2 Pandemic
چکیده انگلیسی مقاله Background: Lung cancer is one of the most frequent neoplasms and is associated with serious oncologic emergencies (OE). We performed a retrospective study to characterize OE in lung cancer patients admitted to the pulmonology department to determine the effects of the SARS-CoV2 pandemic.
Materials and Methods: A total number of 82 patients were admitted with an emergency, mostly brain metastasis (n=37; 45.1%), followed by superior vena cava syndrome (n=13; 15.9%), cardiac tamponade (n=7; 8.5%), large pleural effusion (n=7; 8.5%), severe pulmonary embolism (n=6; 7.3%), spinal cord syndrome (n=6; 7.3%), massive hemoptysis (n=3; 3.7%), stridor (n=2; 2.4%) and atelectasis (n=1; 1.2%). Clinical and pathological data were retrieved from clinical charts including demographic information, smoking status, cancer histology, clinical stage at diagnosis, anticancer treatment, time between LC diagnosis until the OE, outcomes of OE treatment, and overall survival after OE.
Results: The predominant histology was adenocarcinoma (n=59; 71.9%) and 86.8% of the patients (n=71) were in stage IV. OE was the disease presentation in 45.2% (n=37) and 6-month mortality was 75.6%. Neurologic emergencies were associated with a lower risk of 6-month mortality compared to cardiovascular and respiratory [OR 0.255 (CI 0.72-0.90), p=0.035)]. Younger patients (p=0.011), metastatic disease (p=0.02), no cancer treatment (p<0.001), and small cell carcinoma (SCLC) (p=0.016) had a shorter time between cancer diagnosis and the event.
Conclusion: OE occurred mostly in men with metastatic adenocarcinomas. Younger patients, SCLC, metastatic disease, and no cancer treatment were associated with a shorter time between lung cancer diagnosis until the occurrence of an OE and brain metastasis with a better prognosis. There were no differences between patients admitted in 2019 and 2020 that could be related to the access to healthcare services during the SARS-COV2 pandemic.
کلیدواژه‌های انگلیسی مقاله Lung cancer,Oncologic emergencies,SARS-COV2,Pandemic
نویسندگان مقاله Marta Alexandra Carvalho Da Silva |
Department of Pulmonology, Braga Hospital, Portugal.

Sara Campos Silva |
Department of Pulmonology, Braga Hospital, Portugal.

Maria Joana Catarata |
Department of Pulmonology, Braga Hospital, Portugal.

Eva Dias Padrão |
Department of Pulmonology, Braga Hospital, Portugal.

Lurdes Ferreira |
Department of Pulmonology, Braga Hospital, Portugal.

نشانی اینترنتی https://www.tanaffosjournal.ir/article_714792_14b5242d43db6eac3004bb6fcd0b0abe.pdf
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