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Medical Laboratory Journal، جلد ۱۰، شماره ۳، صفحات ۰-۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
In vitro anti-leishmanial effects of garlic extract on Leishmania major: a systematic review |
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| چکیده انگلیسی مقاله |
Background: Leishmaniasis is a parasitic disease that caused by an intracellular protozoa. It is a public health problem in many countries. This project aimed to study the effects of in vitro systematic review of the effects of garlic (Allium sativum) and its compounds on Leishmania major.
Methods: Five English databases (PubMed, Google Scholar, Embase, Scopus, and Web of Science) were searched until the end of December 2022. The syntax and specific tags for each database has been used. The studies with poor methodology, inadequate information, inappropriate analysis, and confusing presentation were excluded from the current study. The quality of articles was assessed by 11 questions developed by the authors and the data were extracted from the selected articles and discussed.
Results: The mostly used solvent for the preparation of garlic extract was distilled water (60%), and methanol (40%). Cell type of J774 was used in one study (20%), and murine peritoneal macrophages were used in the other studies (80%). The bulb of garlic is mostly used. The effect of garlic on Leishmania major was strong. Studies have shown that garlic extract or its active compounds can increase cellular immune responses, which play an important role in inhibiting the Leishmania parasite. This is associated with the activation of macrophages and increased IFN-γ level and NO production.
Conclusion: According to the studies, the effect of different combinations of garlic on the Leishmania parasite has been shown, although the exact mechanism of the anti-leishmanial effect of garlic has not been determined. |
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| کلیدواژه‌های انگلیسی مقاله |
Allium sativum, Garlic. Leishmania major, Systematic review |
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| نویسندگان مقاله |
| Faramarz Koohsar
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan
| Hamed Kalani
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan
| Fatemeh Livani
Infectious Diseases Research Center, Golestan University of Medical Sciences, Gorgan
| Oghol Niaz Jorjani
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan
| Ganesh Yadagiri
College of Veterinary Medicine, Department of Veterinary Biosciences The Ohio State University, Columbus, OHIO-43212 United States of America
| Alireza Ahmadi
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan
| Roghiyeh Faridnia
Laboratory Sciences Research Center, Golestan University of Medical Sciences, Gorgan
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| نشانی اینترنتی |
http://mlj.goums.ac.ir/browse.php?a_code=A-10-1201-1&slc_lang=en&sid=1 |
| فایل مقاله |
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| کد مقاله (doi) |
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| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
انگل شناسی |
| نوع مقاله منتشر شده |
مرور سیستمی |
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