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Iranian Journal of Chemistry and Chemical Engineering، جلد ۴۳، شماره ۱، صفحات ۶۶-۸۲
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| کلیدواژه‌های فارسی مقاله |
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| عنوان انگلیسی |
Fabrication and Characterization of Novel 3D Porous Titanium-6Al-4V Scaffold for Orthopedic Application Using Selective Laser Melting Technique |
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| چکیده انگلیسی مقاله |
The use of metallic 3D printers in medical manufacturing has enabled the creation of complex medical products customized to each patient's specific anatomical information through CAD/CAM. This technology has allowed the examination of three-dimensional (3D) bone scaffolds as models for human bone geometry. Gradually, 3D printing has become a promising tool for creating grafts and scaffolds for bone tissue engineering, particularly in orthopedic fractures. The present study explores the use of a medical-grade titanium alloy coated with chitosan containing wollastonite nanoparticles (WS-NPs) at varying concentrations (0, 5, 10, and 15 wt%) to fabricate a 3D porous metallic scaffold using Selective Laser Melting (SLM). Materials characterization was performed using Scanning Electron Microscopy (SEM) and X-Ray Diffraction (XRD) analysis, while mechanical tests were conducted to determine the compressive strength, fracture toughness, elastic modulus, and Poisson ratio of the samples. The study involved fabricating a 3D porous metallic scaffold using SLM and a medical-grade titanium alloy coated with chitosan containing wollastonite nanoparticles (WS-NPs) at varying concentrations (0, 5, 10, and 15 wt%). The samples were characterized using SEM and XRD analysis, and mechanical tests were conducted to determine their properties. The samples were also subjected to a Simulated Body Fluid (SBF) and phosphate-buffered saline (PBS) test to evaluate their bioactivity and biodegradation rate, as well as an MTT toxicity test. The feasibility of the prostheses was tested for 1, 3, 7, and 14 days, and the results were analyzed. The SEM images and XRD analysis showed the surfaces of scaffold parts produced in nanometer dimensions, confirming the corresponding coating as well as the phases in the scaffold. The sample containing 10 wt% WS-NPs had the highest elastic modulus of about 420 MPa and compressive strength with a coating containing 10 wt% WS-NPs in a chitosan matrix. The results showed that the percentage of porosity changed from 52% to 48% in sample 2 and sample 3, respectively, as the compressive strength increased. The third sample exhibited promising biological behavior for orthopedic applications. The objective of this work is to fabricate and characterize a 3D porous metallic scaffold coated with chitosan containing wollastonite nanoparticles for bone tissue engineering applications. The study successfully fabricated a 3D porous metallic scaffold using SLM and a medical-grade titanium alloy-coated with chitosan containing wollastonite nanoparticles (WS-NPs) at varying concentrations. The results demonstrated that the sample containing 10 wt% WS-NPs had the highest elastic modulus and compressive strength. The third sample exhibited potential for orthopedic applications due to its promising biological behavior. |
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| کلیدواژه‌های انگلیسی مقاله |
Metal 3D printing,Freeze drying,wollastonite,Bio-nanocomposite,Mechanical properties |
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| نویسندگان مقاله |
Ali Attaeyan |
Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, I.R. IRAN
Mohamad Shahgholi |
Department of Mechanical Engineering, Najafabad Branch, Islamic Azad University, Najafabad, I.R. IRAN
Amirsalar Khandan |
Department of Mechanical Engineering, Khomeinishahr Branch, Islamic Azad University, Khomeinishahr, I.R. IRAN
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| نشانی اینترنتی |
https://ijcce.ac.ir/article_707438_7fb62e01bac4d9480874049d9ebbcf2c.pdf |
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| زبان مقاله منتشر شده |
en |
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