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Iranian Journal of Kidney Diseases، جلد ۱۸، شماره ۰۳، صفحات ۱۷۹-۱۸۶
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عنوان انگلیسی Association Between the G82S Polymorphism of the Receptor Gene for Advanced Glycation End-products and Soluble Serum Levels RAGE with Diabetic Nephropathy in the White (Asian) Race
چکیده انگلیسی مقاله Introduction. Diabetic nephropathy is one of the most common severe symptoms of diabetes mellitus. Hyperglycemia can lead to tissue damage and inflammation due to mediators such as receptor for advanced glycation end-products (RAGE). Therefore, in this study, we aimed to investigate the association between the G82S polymorphism of the RAGE gene and diabetic nephropathy in diabetic patients.Methods. In this case-control study, 356 participants (158 men and 198 women) of Asian race, aged 45 to 65 years, who were diagnosed with type 2 diabetes mellitus based on their fasting plasma glucose levels were enrolled. DNA was isolated from the participants’ blood samples and genotyped using TETRA -Primer ARMS-PCR. Serum protein concentration of soluble RAGE (sRAGE) was also determined by enzyme-linked immunosorbent assay (ELISA).Results. Although we found differences in genotyping of participants between homozygous AA and GG and heterozygous GA in the studied groups, the differences were not significant (P = .568). In addition, we found no significant correlation between the G82S polymorphism of RAGE and the development of diabetic nephropathy. Serum levels of sRAGE were only slightly decreased in patients with diabetic nephropathy compared with diabetic patients (P > .05).Conclusion. The results of this study indicate no significant association between the G82S polymorphism in the gene RAGE and the development of diabetic nephropathy. Serum levels of sRAGE were only slightly decreased in patients with diabetic nephropathy compared to diabetic patients without nephropathy. Therefore, the study suggests that there is probably no association between the G82S polymorphism in the gene RAGE and the development of diabetic nephropathy. DOI: 10.52547/ijkd.7872
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نویسندگان مقاله | Asma Rezaei
Student Research Committee, School of Medicine, Qazvin University of Medical Scienc


| Saeede Salemi Bazargani
Student Research Committee, School of Medicine, Qazvin University of Medical Scienc


| Iman Salahshourifar
Department of Biology, Science and Research Branch, Islamic Azad University, Tehran, Iran.


| Sahar Moghbelinejad
Department of Biochemistry and Genetics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran


| Zohreh Abdolvahabi
Department of Biochemistry and Genetics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran


| Hayedeh Yaghoobzadeh
Guilan University of Medical Sciences, Rasht, Iran


| Mojtaba Fathi
Department of Biochemistry and Genetics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran


| Sepideh Hajian
Department of Nephrology, Velayat Hospital, Qazvin University of Medical Sciences, Qazvin, Iran


| Hossein Piri
Department of Biochemistry and Genetics, School of Medicine, Qazvin University of Medical Sciences, Qazvin, Iran Cellular and Molecular Research Center, Research Institute for Non-Communicable Diseases, Qazvin University of Medical Sciences, Qazvin, Iran
نشانی اینترنتی https://ijkd.org/index.php/ijkd/article/view/7872
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کد مقاله (doi) 10.52547/wngvvr19
زبان مقاله منتشر شده en
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نوع مقاله منتشر شده ORIGINAL | Kidney Diseases
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