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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱، صفحات ۵۳-۵۸
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عنوان انگلیسی Antioxidant and antiapoptotic effects of erdosteine in a rat model of ovarian ischemia-reperfusion injury
چکیده انگلیسی مقاله Objective(s): To evaluate the protective effect of erdosteine, an antiapoptotic and antioxidant agent, on torsion–detorsion evoked histopathological changes in experimental ovarian ischemia-reperfusion (IR) injury. Materials and Methods: Eighteen female Wistar albino rats were used in control, IR, and IR+Edosteine (IR-E) groups, (n=6 in each). The IR-E group received the erdosteine for seven days before the induction of torsion/retorsion, (10 mg/kg/days). The IR and IR-E groups were exposed to right unilateral adnexal torsion for 3 hr. Three hours later, re-laparotomy was performed, and the right ovaries were surgically excised. Oxidant and antioxidants levels were determined in serum. The ovarian tissue samples were received and fixed with 10% neutral buffered formalin. The sections were stained with H&E, anti-PCNA, and TUNEL. Results: The IR group were showed severe acute inflammation, polynuclear leukocytes and macrophages, stromal oedema and haemorrhage. Treatment with erdosteine in rats significantly retained degenerative changes in the ovaryPCNA (+) cell numbers were significantly decreased in the IR and IR-E groups unlike the control group. However, its numbers were significantly increased in the IR-E group unlike the IR group. TUNEL (+) cell numbers were significantly increased in the IR group unlike the control and the IR-E groups. In erdosteine treated group, TUNEL (+) cells were detected significantly less than the IR group (P< 0.05). Conclusion: In conclusion, erdosteine maybe a protective agent for ovarian damage and decreasing lipid peroxidation products and leukocytes aggregation after adnexal torsion in animals.
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نویسندگان مقاله vedat ugurel | vedat ugurel
university of trakya, faculty of medicine, department of obstetrics and gynecology, 22030, balkan campus, edirne, turkey


آحمت cagatay cicek | ahmet cagatay cicek
university of trakya, faculty of medicine, department of histology and embryology, 22030, balkan campus, edirne, turkey


مصطفی cemek | mustafa cemek
yildiz technical university, biochemistry division, department of bioengineering, faculty of chemical and metallurgical engineering, istanbul, turkey


selim demirtas | selim demirtas
university of trakya, faculty of medicine, department of histology and embryology, 22030, balkan campus, edirne, turkey


a طوبی kocaman | a tuba kocaman
yildiz technical university, biochemistry division, department of bioengineering, faculty of chemical and metallurgical engineering, istanbul, turkey


توران karaca | turan karaca
university of trakya, faculty of medicine, department of histology and embryology, 22030, balkan campus, edirne, turkey
نشانی اینترنتی http://ijbms.mums.ac.ir/article_8093.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-314615.pdf
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زبان مقاله منتشر شده en
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نوع مقاله منتشر شده Original Article
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