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Iranian Journal of Basic Medical Sciences، جلد ۲۰، شماره ۱، صفحات ۱۷-۲۲
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Chronopharmacological effects of growth hormone on the executive function and oxidative stress response in rats
چکیده انگلیسی مقاله Objective(s): to investigate the chronopharmacological effects of growth hormone on executive function and the oxidative stress response in rats. Materials and Methods: Fifty male Wistar rats (36-40 weeks old) had ad libitum access to water and food and were separated into four groups: diurnal control, nocturnal control, diurnal GH-treated, and nocturnal GH-treated animals. Levels of Cu, Zn superoxide dismutase (Cu,Zn-SOD), and superoxide release by spleen macrophages were evaluated. For memory testing, adaptation and walking in an open field platform was used. GH-treated animals demonstrated better performance in exploratory and spatial open-field tests. Results: The latency time in both GH-treated groups was significantly lower compared with the latency time of the control groups. The diurnal GH treatment did not stimulate superoxide release but increased the CuZn-SOD enzyme levels. The nocturnal GH treatment did not influence the superoxide release and CuZn-SOD concentration. GH treatment also resulted in heart atrophy and lung hypertrophy. Conclusion: Growth hormone treatment improved the performance of executive functions at the cost of oxidative stress triggering, and this effect was dependent on the circadian period of hormone administration. However, GH treatment caused damaging effects such as lung hypertrophy and heart atrophy.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله کارلوس k b ferrari | carlos k b ferrari
federal university of mato grosso ufmt , mato grosso, brazil


eduardo l frança | eduardo l frança
federal university of mato grosso ufmt , mato grosso, brazil|são paulo state university unesp , são paulo, brazil


luciane a monteiro | luciane a monteiro
university center of araxá uniaraxa , minas gerais, brazil


برونو l سانتوز | bruno l santos
university center of araxá uniaraxa , minas gerais, brazil


alfredo pereira junior | alfredo pereira junior
são paulo state university unesp , são paulo, brazil


adenilda honorio frança | adenilda honorio frança
federal university of mato grosso ufmt , mato grosso, brazil|são paulo state university unesp , são paulo, brazil
نشانی اینترنتی http://ijbms.mums.ac.ir/article_8087.html
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/87/article-87-314609.pdf
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده Original Article
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