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International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۱، شماره ۱، صفحات ۱۹-۲۳
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عنوان انگلیسی Frequency of M287T/AS3MT Single Nucleotide Polymorphism in an Iranian Population
چکیده انگلیسی مقاله Background : To determine the frequency of the single nucleotide polymorphism M287T in exon 9 of the AS3MT gene in Iranian population and to assess the difference in allele frequencies with other ethnicities. Subjects and Methods : Genotyping analysis was performed on 150 healthy subjects using the PCR-RFLP assay. We used chi-square analysis to check the deviation from Hardy–Weinberg equilibrium and compare of the observed genotype frequencies in various ethnic. The level of statistical significance was considered as p< 0.05. Results : The homozygous CC, homozygous TT and heterozygous CT genotypes were observed in 2%, 80% and 18% of participated individuals. The SNP rs11191439 passed the Hardy-Weinberg equilibrium chi-squared test with p-value>0.05 and had a minor allele frequency (MAF)>5%. Conclusion : Iranians are genetically very similar to Caucasian and African individuals and they are considerably different from other East Asians including Koreans, Chinese and Japanese individuals. Due to genetic polymorphisms can contribute to the variability in AS3MT activity; they may contribute to interindividual as well as intra-ethnic differences in response to the detoxification of arsenic.
کلیدواژه‌های انگلیسی مقاله AS3MT gene, Polymorphism, Arsenic
نویسندگان مقاله فاطمه فرهید | fatemeh farhid
msc, department of hematology, school of allied medical sciences, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

فاطمه نادعلی | fatemeh nadali
associate professor, department of hematology, school of allied medical sciences, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

بهرام چهاردولی | bahram chahardouli
assistant professor, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

سعید محمدی | saeed mohammadi
phd, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

شهربانو رستمی | shahrbano rostami
assistant professor, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

کامران علی مقدم | kamran alimoghaddam
professor, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

اردشیر قوام زاده | ardeshir ghavamzadeh
professor, hematology-oncology and stem cell transplantation research center, tehran university of medical sciences, tehran, iran

سازمان اصلی تایید شده: دانشگاه علوم پزشکی تهران (Tehran university of medical sciences)

نشانی اینترنتی http://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/666
فایل مقاله اشکال در دسترسی به فایل - ./files/site1/rds_journals/78/article-78-314388.pdf
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زبان مقاله منتشر شده en
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