این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Hematology-Oncology and Stem Cell Research، جلد ۱۸، شماره ۲، صفحات ۱۴۰-۱۴۶
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Serum Interleukin 6 (IL -6) as Prognostic Marker in Egyptian CLL patients
چکیده انگلیسی مقاله Background: Chronic lymphocytic leukemia (CLL) is the most common leukemia in adults. Currently, several biomarkers are being used as CLL prognosticators, including elevated protein levels, elevated RNA levels, gene mutations, and epigenetic changes. Materials and Methods: This study is a prospective study conducted on 55 patients newly diagnosed with CLL, serum IL-6 level was measured initially and after a 6-month treatment course. Correlation with the course of the disease and the known CLL prognostic parameters was done initially and after 6 months. Results: The initial serum IL-6 level in the patient group (pre-treatment) ranges from 36-91 pg/mL (median 57), and in the patient group (post-treatment) ranges from 1-32 pg/mL (median 2). Serum IL-6 level was positively correlated with WBC count, β2 microglobulin, LDH, ESR, B symptoms, Uric Acid, BM Aspirate (% of lymphocytes), and Binet and Rai staging systems. Conclusion: Serum IL-6 is a useful poor prognostic marker in newly diagnosed CLL patients; its prognostic value goes with the other known prognostic markers such as the BM lymphocyte count, ESR, and LDH.
کلیدواژه‌های انگلیسی مقاله
نویسندگان مقاله | Essam Hassan
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt


| Emad Abdelhady
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt


| Hanaa Abdelsamee
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt


| Mohamed Sallam
Department of Clinical Pathology, Faculty of Medicine, Ain Shams University, Cairo, Egypt


| Mostafa El-Razzaz
Department of Internal Medicine, Faculty of Medicine, Ain Shams University, Cairo, Egypt
نشانی اینترنتی https://ijhoscr.tums.ac.ir/index.php/ijhoscr/article/view/1541
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات