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Tanaffos، جلد ۲۲، شماره ۲، صفحات ۲۳۰-۲۳۵
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عنوان انگلیسی Effect of Oral Caffeine on Weaning from Mechanical Ventilation in Intubated ICU Patients
چکیده انگلیسی مقاله Background: The role of caffeine as a brain stimulant in improving the respiratory characteristics of patients under mechanical ventilation is unclear. This study aimed at determining the effect of oral caffeine in helping to release (Liberation) from the ventilator in intubated patients under mechanical ventilation admitted to the intensive care unit. Materials and Methods: General ICU patients with more than 48 hours of dependency on a ventilator were randomly divided into two groups. The intervention group received 200mg caffeine tablets twice a day through a gastric tube, while the control group received a placebo of the same amount. Every day, patients were assessed for the likelihood of being disconnected from the device. If their clinical condition was deemed suitable, the device mode was switched to spontaneous, and their Rapid Shallow Breathing Index (RSBI) was calculated. Based on this information, a decision was made regarding whether to proceed with weaning. Results: Caffeine use in ICU patients significantly reduced the airway resistance index of patients (P <0.05). However, although this drug reduced the length of hospital stay in the ICU and the duration of intubation of patients, these changes were not statistically significant (P> 0.05). Conclusion: Caffeine may improve respiratory status and reduce the duration of intubation and hospitalization in the ICU.
کلیدواژه‌های انگلیسی مقاله Caffeine, Intubation, ICU, Respiratory system, Mechanical ventilator
نویسندگان مقاله Seyedpouzhia Shojaei |
Department of Anesthesiology And Critical Care, Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Alireza Ebrahimi |
Department of Anesthesiology And Critical Care, Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mir Mohammad Miri |
Department of Anesthesiology And Critical Care, Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mehran Kouchek |
Department of Anesthesiology And Critical Care, Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Sara Salarian |
Department of Anesthesiology And Critical Care, Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Mohammad Sistanizad |
Department of Clinical Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Behnam Arabzadeh |
Department of Anesthesiology And Critical Care, Critical Care Quality Improvement Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Nazanin Hajizadeh |
Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran

Padideh Ansar |
Department of Anesthesiology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.

نشانی اینترنتی https://www.tanaffosjournal.ir/article_711925_fd959e749823331781fc0b8ec7f8af90.pdf
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