این سایت در حال حاضر پشتیبانی نمی شود و امکان دارد داده های نشریات بروز نباشند
International Journal of Pediatrics، جلد ۱۲، شماره ۱، صفحات ۱۸۴۷۴-۱۸۴۸۳
عنوان فارسی
چکیده فارسی مقاله
کلیدواژه‌های فارسی مقاله
عنوان انگلیسی Bone Mineral Density in Patients with Phenylketonuria in Iran
چکیده انگلیسی مقاله Background: Factors like low-protein diet may impose Phenylketonuria (PKU) patients to impaired skeletal disease. The present study assessed the status of Bone Mineral Density (BMD) among PKU patients on a low-protein diet. Methods: A cross-sectional study was conducted (Tehran, Iran, 2019). Patients aged ≥ 4 years old with a definite diagnosis of PKU on a low-protein diet were included. BMD values of the lumbar spine and femoral neck were assessed. The primary objective was assessing femoral and lumbar BMD status in PKU patients. Results: Forty-one PKU patients entered the study. The mean BMI was 20.712±4.833 Kg/m2. The mean bone age was significantly lower than chronological age (10.9 vs. 12.4 years; P=0.008). The results showed a bone mass reduction in 23.1% of all patients.  A significant correlation was observed between lumbar and femoral BMD values (P=0.001; r=0.516). Most patients (about 77%) had lumbar Z-scores>-1 and 10.3% showed Z-scores in the range of osteoporosis. Age (P=0.004) and age at diagnosis (P=0.002) were the influencing factors on BMD status. The results showed a significantly inverse correlation between BMD lumbar levels with the patient’s chronological age (P=0.016), age of PKU diagnosis (P=0.002), and phenylalanine level (P=0.025) Conclusion: The results delineated impaired skeletal status among PKU patients on a low-protein diet. Lumbar Z-score values inversely correlated with the patient’s chronological age, age at PKU diagnosis, and phenylalanine level. Hence, early PKU diagnosis and treatment during neonatal period, as well as controlling phenylalanine concentration may improve BMD status.
کلیدواژه‌های انگلیسی مقاله PKU, BMD, Phenylketonuria, Osteopenia, Osteoporosis
نویسندگان مقاله | Aria Setoodeh
Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Samaneh Onsori
Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Parastoo Rostami
Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Ali Rabbani
Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran.


| Farzaneh Abbasi
Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Fatemeh Sayarifard
Children’s Medical Center, Pediatrics Center of Excellence, Tehran University of Medical Sciences, Tehran, Iran. Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran


| Reza Tavakolizadeh
Growth and Development Research Center, Tehran University of Medical Sciences, Tehran, Iran. Department of Pediatrics, Tehran University of Medical Sciences, Tehran, Iran. Maternal, Fetal & Neonatal Research Center, Family Health
نشانی اینترنتی https://ijp.mums.ac.ir/article_23767.html
فایل مقاله فایلی برای مقاله ذخیره نشده است
کد مقاله (doi)
زبان مقاله منتشر شده en
موضوعات مقاله منتشر شده
نوع مقاله منتشر شده original article
برگشت به: صفحه اول پایگاه   |   نسخه مرتبط   |   نشریه مرتبط   |   فهرست نشریات