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International journal of Advanced Biological and Biomedical Research، جلد ۳، شماره ۳، صفحات ۲۲۲-۲۳۰
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| عنوان فارسی |
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| چکیده فارسی مقاله |
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| عنوان انگلیسی |
Tocotrienol Modulates the Expression of Proteins in Oxidative Stress-Induced Caenorhabditis Elegans |
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| چکیده انگلیسی مقاله |
Objective: Oxidative stress that damages proteins result in aging and age related diseases. The aim of this study is to determine the effect of tocotrienol rich fraction (TRF) on the expression of proteins in oxidative stress-induced caenohabditis elegans (C.elegans) which has homologous genes to humans. Methods: The worms were treated with TRF prior to, after and continuously in separate groups upon induction of oxidative stress with hydrogen peroxide. The expression of proteins were analyzed with 2D-gel electrophoresis and identified with mass spectrophotometry. Results showed that induction of oxidative stress and TRF treatment separately modulated the expression of 11 proteins. Pre-treatment of TRF altered the expression of 5 proteins while post-treatment and a continuous treatment of TRF in oxidative stress-induced worms affected the expression of 9 and 10 proteins respectively. Results: From these differentially expressed proteins, a total of 12 were successfully identified. TRF was found to increase the expression of glutathione-S transferase but decreased the expression of mRNA cap guanine-N7 methyltransferase, inorganic pyro-phosphatase, enoyle-CoA hydratase, vitellogenin 6 precursor, cathepsin B-like cysteine proteinase 4 precursor, triosephosphatase isomerase, tubulin-specific chaperon B and putative D-amino acid oxidase. In conclusion, TRF modulated the expression of proteins involved in energy metabolism, oxidative stress, proteolysis and biosynthesis of mRNA in C.elegans. |
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| کلیدواژه‌های انگلیسی مقاله |
Development of cities,green space,Promotion of environmental |
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| نویسندگان مقاله |
goon jo aan | jo aan
department of biochemistry, universiti kebangsaan malaysia medical center, jalan yaacob latif, 56000 kuala lumpur, malaysia
محمد shahril aszrin zainudin | mohd shahril aszrin zainudin
department of biochemistry, universiti kebangsaan malaysia medical center, kuala lumpur, malaysia
noralisa عبد الکریم | abdul karim
department of biochemistry, universiti kebangsaan malaysia medical center, kuala lumpur, malaysia
choor chee ken | chee ken
department of biochemistry, universiti kebangsaan malaysia medical center, kuala lumpur, malaysia
wan zurinah wan ngah | wan zurinah wan ngah
department of biochemistry, universiti kebangsaan malaysia medical center, kuala lumpur, malaysia
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| نشانی اینترنتی |
http://www.ijabbr.com/article_14243_b0868280f64a7e489d3fd6a12a2d29f1.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2255/article-2255-303041.pdf |
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| زبان مقاله منتشر شده |
en |
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