|
|
Nanomedicine Research Journal، جلد ۱، شماره ۲، صفحات ۹۰-۹۶
|
|
|
| عنوان فارسی |
|
|
| چکیده فارسی مقاله |
|
|
| کلیدواژه‌های فارسی مقاله |
|
|
| عنوان انگلیسی |
Mathematical Kinetic Modeling on Isoniazid Release from Dex-HEMA-PNIPAAm Nanogels |
|
| چکیده انگلیسی مقاله |
Objective(s): The quantitative calculation of release data is more facil when mathematics come to help. mathematically modeling could aid optimizing and amending the delivery systems design. Aim of this study is to find out the isoniazid release kinetic. Methods: In this work degradable temperature sensitive dextran-hydroxy ethyl methacrylate- poly-N-isopropyl acryl amide (Dex-HEMA-PNIPAAm) nanogels which were synthesized by UV polymerization were loaded by Isoniazid. The Isoniazid release amounts taken from in vitro studies at two different temperatures, below and upper lower criticalsolution temperature (LCST) were mathematically modeled to investigate the kinetic of drug release. Mathematically inquiry of release phenomenon of Isoniazid makes it easy to predict and recognize the influence of delivery device laying out parameters on release kinetic formulation. The modeling was performed using model dependent methods, such as zero order, first order, Higuchi, Korsmeyer- Pepas, Hixon and Crowel. Results: The best fitted model showing the highest determination coefficient (R2) was Korsmeyer-Pepas which means predominant release mechanism is controlled by diffusion. Conclusions: The Isoniazid release pattern of most samples was combination of swelling, diffusion and degradation. |
|
| کلیدواژه‌های انگلیسی مقاله |
Release kinetic,Modeling,Zero order,First order,Higuchi |
|
| نویسندگان مقاله |
مریم جعفری |
chemical engineering department, engineering faculty, university of tehran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
بابک کفاشی |
chemical engineering department, engineering faculty, university of tehran
سازمان اصلی تایید شده: دانشگاه تهران (Tehran university)
|
|
| نشانی اینترنتی |
http://www.nanomedicine-rj.com/article_21159_ef299cad41a53e6849388eb12b6f632c.pdf |
| فایل مقاله |
اشکال در دسترسی به فایل - ./files/site1/rds_journals/2250/article-2250-302409.pdf |
| کد مقاله (doi) |
|
| زبان مقاله منتشر شده |
en |
| موضوعات مقاله منتشر شده |
|
| نوع مقاله منتشر شده |
|
|
|
|
برگشت به:
صفحه اول پایگاه |
نسخه مرتبط |
نشریه مرتبط |
فهرست نشریات
|